| Project/Area Number |
23780121
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Bioproduction chemistry/Bioorganic chemistry
|
|---|
| Research Institution | Tokyo University of Agriculture |
|---|
Principal Investigator |
KATSUTA Ryo 東京農業大学, 応用生物科学部, 助教 (00553257)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
|
|---|
| Keywords | 有機化学 / 天然物化学 / versipelostatin / GRP78 / 抗腫瘍 / 生理活性物質 / 天然物合成 / 抗がん / シャペロン / Claisen転位 / GRP 78 |
|---|
| Research Abstract |
Recently, an importance of cancer in cause of death is increasing, especially in advanced nations. To improve the new class of anticancer agent, the synthetic study of versipelostatin(VST) A, a microbe derived molecular chaperon suppressor, is performed. In this research program, syntheses of all fragment required for VST synthesis including its specific part, spirotetronate fragment was achieved.
|
