| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Research Abstract |
We searched sensor molecules involved in dietary protein/peptide-sensing in enteroendocrine cells. By using enteroendocrine cell models, we found that a TRP channel was highly expressed in CCK-producing cell line.
It was demonstrated that the TRP channel is involved in alpha-casein-induced CCK secretion. Furthermore, an aldehyde was found to induce CCK secretion through the TRP channel. Oral administration of the aldehyde reduced gastric emptying rate in rats, suggesting the aldehyde directly acts enteroendocrine cell and reduces gastric emptying in vivo.
In separated experiments, we found that calcium-sensing receptor functions as sensor for various protein hydrolysates, rather than for specific peptides.
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