Enzymatic synthesis of polyphenol-glycosides with stimulatory activity on Treg differentiation
| Project/Area Number |
23780129
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Food science
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| Research Institution | Shinshu University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 食品機能 / 免疫寛容 / ポリフェノール / 配糖体 / アレルギー |
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| Research Abstract |
We synthesized newly polyphenol glycosides via a rutinase-catalyzed transglycosylation reaction. We then prepared a newly in vitro assay system using DCs differentiated from human monocytic THP-1 for the screening of anti-allergic compounds. Significant decrease in HLA-DR expression was observed in the apple procyanidins and caffeic acid-rutinosides-treated cells in the stimulation of OVA. These suggest that the newly developed polyphenols glycosides should be contribute to anti-allergic agents with suppressive effect on antigen presentation.
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Report
(3 results)
Research Products
(12 results)
