Protective role of flavonoids in the stress-induced intestinal barrier dysfunction
| Project/Area Number |
23780135
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Food science
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| Research Institution | Hiroshima University |
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Principal Investigator |
SUZUKI Takuya 広島大学, 大学院・生物圏科学研究科, 准教授 (30526695)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | フラボノイド / ストレス / 消化管バリア / 消化管バリア機能 |
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| Research Abstract |
In this study, we investigated the ameliorative effects of flavonoids on the stress-induced intestinal barrier defect. Two flavonoids, quercetin and hesperetin, affect the expression and distribution of tight junction proteins, resulting in the increased integrity of intestinal barrier. These findings indicate the novel function of dietary flavonoids and could contribute to the intestinal health.
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Report
(3 results)
Research Products
(45 results)
