| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Research Abstract |
Defects in insulin secretion by decreasing pancreatic β-cell mass are frequently observed in patients with type 2 diabetes in eastern country. We have demonstrated that male sexual hormone (testosterone) enhanced the proliferation of β-cellthrough androgen receptor (AR). The growth stimulating effects of testosterone was diminished under high glucose conditions, which decreased AR protein. We also found that S-equol, which is produced from the soy isoflavone daidzein, enhanced β-cell growth.
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