Studies of biological functions of sulfated metabolites from foods
Project/Area Number |
23780143
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Food science
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Research Institution | Tokai University |
Principal Investigator |
YASUDA SHIN 東海大学, 農学部, 准教授 (10512923)
|
Project Period (FY) |
2011-04-28 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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Keywords | 代謝物 / 抱合体 / 硫酸体 / 生理機能性 / フェノール性化合物 / ポリフェノール / 抗酸化 / 活性酸素 |
Outline of Final Research Achievements |
A part of phenolic constituents of foods have been considered to play an important role on preventing lifestyle-related diseases or lowering disease risks. However, the phenolic compounds such as polyphenols are known to undergo circulation and excretion as their conjugated form after the hepatic and intestinal metabolic transformation in our body. Whether the conjugation of these compounds by sulfation may enhance their physiological functions, remains unclear. The current study aimed to investigate whether a sulfated form of certain phenolic compound could demonstrate any biological functions as a model. Antioxidant analyses revealed that the sulfated metabolite was capable of showing suppressive effect rather than its unconjugated form upon a reactive oxygen generation system in vitro.
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Report
(5 results)
Research Products
(11 results)
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[Presentation] Inhibitory effect of p-nitrophenyl O-sulfate on the O2- radical production.2014
Author(s)
Sugahara, S., Takeuchi, R., Ono, M., Igoshi, K., Kurogi, K., Sakakibara, Y., Suiko, M., Liu, M.-C., Yasuda, S.
Organizer
In poster session, 12th International Symposium on Cytochrome P450. P450 Biodiversity and Biotechnology.
Place of Presentation
Kyoto International Community House, Kyoto, Japan
Year and Date
2014-09-24 – 2014-09-28
Related Report
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[Presentation] Japan’s Functional Food Trend in 21th Century.2014
Author(s)
Shin Yasuda.
Organizer
In Seminar: Thai Health Food Industry Leveraging to World Class Market. Hosted by Faculty of Agro-Industry, KMITL.
Place of Presentation
Pullman Bangkok King Power Hotel, Bangkok, Thailand
Year and Date
2014-08-30
Related Report
Invited
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[Presentation] Mechanism of the suppression by p-nitrophenol O-sulfate on the reactive oxygen generation systems.2013
Author(s)
Sugahara, S., Takeuchi, R., Ono, M., Igoshi, K., Yasuda, S.
Organizer
In poster session, 17th Asian Agricultural Symposium
Place of Presentation
Tokai University, Kumamoto, Japan
Related Report
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