| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Research Abstract |
We found that MLN-DC of vitamin A-deficient mice induced IL-13-producing inflammatory T cells, and that oral administration of antigen to these mice failed to induce immune tolerance but primed for strong IL-13-dependent IgG1 responses followed by IgE responses. Vitamin A deficiency enhanced TNF-α expression in the proximal colon, and that might further stimulate MLN-DC to induce IL-13-producing T cells. These results suggest that vitamin A plays critical roles in the inhibition of inflammatory or allergic responses to oral antigens partly through modulating the intestinal microenvironment and the nature of MLN-DC.
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