| Project/Area Number |
23780149
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Food science
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| Research Institution | National Agriculture and Food Research Organization |
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Principal Investigator |
WATANABE Jun 独立行政法人農業・食品産業技術総合研究機構, 食品総合研究所・食品機能研究領域, 主任研究員 (10374729)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | 食物アレルギー / 腸内細菌 / 経母乳感作 / 腸内常在細菌叢 |
|---|
| Research Abstract |
The aim of this study was to clarify the relationship between intestinal microbiota and allergy development and the effect of maternal allergen intake during lactating period on immune reactions in offspring. Microbiota was changed in the intestine of DO11.10 mice, when those were sensitized by oral OVA administration. Maternal diet affected severity of allergic reactions probably via changing in the intestinal microbiota in offspring. Native antigen was observed in breast milk after the perinatal maternal exposure of oral antigen, with resulting sensitization in offspring. However, the sensitization was not enough to induce allergic reactions, and maternal allergen exposure did not affect the severity of allergic reactions after the additional sensitization.
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