Identification of TNF pathway modulator and implications for immune response in kuruma shrimp
Project/Area Number |
23780207
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
General fisheries
|
Research Institution | Fisheries Research Agency |
Principal Investigator |
MEKATA Tohru 独立行政法人水産総合研究センター, 増養殖研究所病害防除部, 研究員 (40597944)
|
Project Period (FY) |
2011 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 水族生体防御 / クルマエビ / 生体防御 / プロテオーム解析 / 腫瘍壊死因子 / RNA干渉 / 腫瘍壊死因子受容体 / RNA干渉法 |
Research Abstract |
To gain an insight of the function of shrimp TNF at protein level, proteome analysis has been done in kuruma shrimp (Marsupenaeus japonicus) with recombinant TNF administration, gene silencing by dsRNA, and pathogen stimulation. Putative s-adenosylhomocysteine hydrolase were up-regulated after recombinant TNF injection and down-regulated after gene knockdown and exposure to pathogens.
|
Report
(3 results)
Research Products
(26 results)