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Effects of cytokines on the regulation of adaptive immunity in fish

Research Project

Project/Area Number 23780211
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Fisheries chemistry
Research InstitutionTokyo University of Marine Science and Technology

Principal Investigator

KONDO Hidehiro  東京海洋大学, 海洋科学技術研究科, 准教授 (20314635)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
KeywordsDNA ワクチン / 遺伝子発現 / 獲得免疫 / 抗体価 / サイトカイン / 魚類免疫 / ワクチン / アジュバント / ヒラメ
Research Abstract

In this research aimed to reveal the function of cytokines in the regulation of adaptive immunity. The research is divided into three parts. First, some novel cytokine genes were identified in Japanese flounder Paralichthys olivaceus including 2 novel interleukin (IL) 1 like genes, 4 types of IL-12 family component genes, and 4 novel chemokine genes. Second, the role of IL-1- in the regulation of adaptive immunity was evaluated. The cytokine enhanced specific antibody titers against protein antigen and DNA vaccine in Japanese flounder. Third, the functional mechanisms of type I interferon system in fish were investigated.

Report

(3 results)
  • 2013 Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Research-status Report
  • Research Products

    (21 results)

All 2013 2012 2011 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (20 results)

  • [Journal Article] Identification of novel interleukin 1 beta family genes in Japanese flounder Paralichthys olivaceus.2012

    • Author(s)
      Apichaya Taechavasonyoo, Hidehiro Kondo, Reiko Nozaki, Yutaka Suzuki, Ikuo Hirono
    • Journal Title

      Fish Shellfish Immunol

      Volume: 34 Issue: 1 Pages: 393-396

    • DOI

      10.1016/j.fsi.2012.10.001

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] マハタにおける温度依存的な自然免疫関連遺伝子の発現に関する研究2013

    • Author(s)
      坂井二千佳、山下浩史、近藤秀裕、廣野育生
    • Organizer
      平成24年度日本水産学会春季大会
    • Place of Presentation
      東京海洋大学、東京都
    • Year and Date
      2013-03-29
    • Related Report
      2013 Final Research Report
  • [Presentation] ヒラメEpstein-Barrvirus-inducedgene3遺伝子の構造および発現解析2013

    • Author(s)
      杉山巴美、近藤秀裕、廣野育生.
    • Organizer
      平成25年度日本水産学会春季大会
    • Place of Presentation
      東京海洋大学、東京都
    • Year and Date
      2013-03-28
    • Related Report
      2013 Final Research Report
  • [Presentation] The immuno-adjuvant effect of interleukin-1β in Japanese flounder (Paralichthys olivaceus)2012

    • Author(s)
      Apichaya Taechavasonyoo, Hirono I, Kondo H.
    • Organizer
      International Society of Developmental and Comparative Immunology
    • Place of Presentation
      福岡シーホーク、福岡県
    • Year and Date
      2012-07-10
    • Related Report
      2013 Final Research Report
  • [Presentation] Identification of 2 novel interleukin 1 beta family genes in Japaneseflounder Paralichthys olivaceus2012

    • Author(s)
      Kondo H, Taechavasonyoo A, Suzuki Y, Hirono I.
    • Organizer
      International Plant & Animal Genome XX
    • Place of Presentation
      サンディエゴ、ア メリカ
    • Year and Date
      2012-04-14
    • Related Report
      2013 Final Research Report
  • [Presentation] Theimmuno-adjuvanteffectofJapaneseflounder(Paralichthysolivaceus)interleukin-1βonimmuneresponse2012

    • Author(s)
      TaechavasonyooA,HironoI,KondoH.
    • Organizer
      平成24年度日本水産学会春季大会
    • Place of Presentation
      東京海洋大学、東京都
    • Year and Date
      2012-03-29
    • Related Report
      2013 Final Research Report
  • [Presentation] Cloning of Japanese flounder (Paralichthys olivaceus) interleukin-12 p40 and p352012

    • Author(s)
      Taechavasonyoo A, Kondo H, Hirono I.
    • Organizer
      平成24年度日本魚病学会春季大会
    • Place of Presentation
      東京海洋大学、東京都
    • Year and Date
      2012-03-18
    • Related Report
      2013 Final Research Report
  • [Presentation] Temperature-dependent regulation of Mx protein gene expression in fish culture cells2011

    • Author(s)
      Sakai N, Kondo H, Hirono I.
    • Organizer
      Genomics in Aquaculture 2011
    • Place of Presentation
      クレタ、ギリシア
    • Year and Date
      2011-09-15
    • Related Report
      2013 Final Research Report
  • [Presentation] The cytokines profiling of Japanese flounder Paralichthys olivaceus injected with expression vector and recombinant IL-12011

    • Author(s)
      Taechavasonyoo A, Hirono I, Kondo H.
    • Organizer
      15th International Conference on Diseases of Fish and Shellfish organized by the EAFP
    • Place of Presentation
      スプリット、クロ アチア
    • Year and Date
      2011-09-14
    • Related Report
      2013 Final Research Report
  • [Presentation] ヒラメ新規ケモカインの発現解析2011

    • Author(s)
      井上僚、加藤豪司、近藤秀裕 、廣野育生
    • Organizer
      第14回マリンバイオテクノロジー学会
    • Place of Presentation
      静岡県コンベンション アーツセンター、静岡市
    • Year and Date
      2011-05-28
    • Related Report
      2013 Final Research Report
  • [Presentation] 魚類における温度依存的な自然免疫活性化に関する研究2011

    • Author(s)
      坂井二千佳、岡田峻、近藤秀裕、廣野育生
    • Organizer
      第14回マリンバイオテクノロジー学会
    • Place of Presentation
      静岡県コンベンションアーツセンター、静岡市
    • Year and Date
      2011-05-28
    • Related Report
      2013 Final Research Report
  • [Presentation] The immuno-adjuvant effect of interleukin-1β in Japanese flounder (Paralichthys olivaceus)

    • Author(s)
      Apichaya Taechavasonyoo, Ikuo Hirono, Hidehiro Kondo
    • Organizer
      International Society of Development and Comparative Immunity
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] ヒラメ Epstein-Barr virus-induced gene 3 遺伝子の 構造および発現解析

    • Author(s)
      杉山巴美・近藤秀裕・廣野育生(海洋大)
    • Organizer
      平成25年度日本水産学会春季大会
    • Place of Presentation
      東京海洋大学、品川
    • Related Report
      2012 Annual Research Report
  • [Presentation] 魚類における温度依存的な自然免疫活性化に関する研究

    • Author(s)
      坂井二千佳、岡田峻、近藤秀裕、廣野育生
    • Organizer
      第14回マリンバイオテクノロジー学会
    • Place of Presentation
      静岡県静岡市
    • Related Report
      2011 Research-status Report
  • [Presentation] ヒラメ新規ケモカインの発現解析

    • Author(s)
      井上僚、加藤豪司、近藤秀裕、廣野育生
    • Organizer
      第14回マリンバイオテクノロジー学会
    • Place of Presentation
      静岡県静岡市
    • Related Report
      2011 Research-status Report
  • [Presentation] THE CYTOKINES PROFILING OF JAPANESE FLOUNDER PARALICHTHYS OLIVACEUS INJECTED WITH EXPRESSION VECTOR AND RECOMBINANT IL-1β

    • Author(s)
      Taechavasonyoo A, Hirono I, Kondo H
    • Organizer
      第15回ヨーロッパ魚病学会大会
    • Place of Presentation
      スプリット、クロアチア
    • Related Report
      2011 Research-status Report
  • [Presentation] TEMPERATURE-DEPENDENT REGULATION OF MX PROTEIN GENE EXPRESSION IN FISH CULTURE CELLS

    • Author(s)
      Sakai N, Kondo H, Hirono I
    • Organizer
      水産養殖ゲノム会議
    • Place of Presentation
      イラクリオン、ギリシャ
    • Related Report
      2011 Research-status Report
  • [Presentation] Identification of 2 novel interleukin 1 beta family genes in Japanese flounder Paralichthys olivaceus

    • Author(s)
      Kondo H, Taechavasonyoo A, Suzuki Y, Hirono I
    • Organizer
      動植物ゲノム会議
    • Place of Presentation
      サンディエゴ、アメリカ
    • Related Report
      2011 Research-status Report
  • [Presentation] Cloning of Japanese flounder(Paralichthys olivaceus)interleukin-12 p40 and p35

    • Author(s)
      Taechavasonyoo A, Hirono I, Kondo H
    • Organizer
      平成24年度日本魚病学会春季大会
    • Place of Presentation
      東京都港区
    • Related Report
      2011 Research-status Report
  • [Presentation] The immuno-adjuvant effect of Japanese flounder (Paralichthys olivaceus) interleukin-1β on immune response

    • Author(s)
      Taechavasonyoo A, Kondo H, Hirono I
    • Organizer
      平成24年度日本水産学会春季大会
    • Place of Presentation
      東京都港区
    • Related Report
      2011 Research-status Report
  • [Presentation] マハタにおける温度依存的な自然免疫関連遺伝子の発現に関する研究

    • Author(s)
      坂井二千佳、山下浩史、近藤秀裕、廣野育生
    • Organizer
      平成24年度日本水産学会春季大会
    • Place of Presentation
      東京都港区
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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