| Project/Area Number |
23780211
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Fisheries chemistry
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| Research Institution | Tokyo University of Marine Science and Technology |
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Principal Investigator |
KONDO Hidehiro 東京海洋大学, 海洋科学技術研究科, 准教授 (20314635)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | DNA ワクチン / 遺伝子発現 / 獲得免疫 / 抗体価 / サイトカイン / 魚類免疫 / ワクチン / アジュバント / ヒラメ |
|---|
| Research Abstract |
In this research aimed to reveal the function of cytokines in the regulation of adaptive immunity. The research is divided into three parts. First, some novel cytokine genes were identified in Japanese flounder Paralichthys olivaceus including 2 novel interleukin (IL) 1 like genes, 4 types of IL-12 family component genes, and 4 novel chemokine genes. Second, the role of IL-1- in the regulation of adaptive immunity was evaluated. The cytokine enhanced specific antibody titers against protein antigen and DNA vaccine in Japanese flounder. Third, the functional mechanisms of type I interferon system in fish were investigated.
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