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Environmental Control for Rapid Production of an Influenza VaccineAntigen using Plants

Research Project

Project/Area Number 23780255
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Agricultural environmental engineering
Research InstitutionThe University of Tokyo

Principal Investigator

MATSUDA Ryo  東京大学, 大学院・農学生命科学研究科, 講師 (20547228)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords一過性遺伝子発現 / ウイルスベクター / インフルエンザワクチン / 環境調節 / ベンサミアナタバコ / ヘマグルチニン / 気温 / 光合成有効光量子束密度 / 一過的遺伝子発現 / 物理環境調節 / 植物利用型医薬用物質生産
Research Abstract

Effects of plant growing conditions such as physical environment on the level of recombinant influenza hemagglutinin accumulation were investigated in a viral vector-based transient gene expression system. We found that air temperature post viral-vector inoculation was an important environmental variable for enhancing hemagglutinin productivity. We also suggested that vacuum infiltration of plant aerial parts can be improved for increasing the efficiency of vector inoculation.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (5 results)

All 2012 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (4 results)

  • [Journal Article] Virus Vector-Mediated Rapid Protein Production in <I>Nicotiana benthamiana</I>: Effects of Temperature and Photosynthetic Photon Flux Density on Hemagglutinin Accumulation2012

    • Author(s)
      松田怜,田原亜希,的場伸行,富士原和宏
    • Journal Title

      Environment Control in Biology

      Volume: 50 Issue: 4 Pages: 375-381

    • DOI

      10.2525/ecb.50.375

    • NAID

      10031136574

    • ISSN
      1880-554X, 1883-0986
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Presentation] 一過性遺伝子発現による植物利用型ワクチン生産:遺伝子導入後の気温と光強度がワクチン含量に及ぼす影響2012

    • Author(s)
      松田怜ら
    • Organizer
      日本生物環境工学会2012年東京大会
    • Place of Presentation
      東京大学
    • Year and Date
      2012-09-05
    • Related Report
      2012 Final Research Report
  • [Presentation] 一過性遺伝子発現法における遺伝子導入前の液肥窒素濃度がベンサミアナタバコ葉内ワクチン含量に及ぼす影響2012

    • Author(s)
      藤内直道ら
    • Organizer
      日本生物環境工学会2012年東京大会
    • Place of Presentation
      東京大学
    • Year and Date
      2012-09-05
    • Related Report
      2012 Final Research Report
  • [Presentation] 一過性遺伝子発現による植物利用型ワクチン生産: 遺伝子導入後の気温と光強度がワクチン含量に及ぼす影響

    • Author(s)
      松田ら
    • Organizer
      日本生物環境工学会2012年東京大会
    • Place of Presentation
      東京大学(東京)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 一過性遺伝子発現法における遺伝子導入前の液肥窒素濃度がベンサミアナタバコ葉内ワクチン含量に及ぼす影響

    • Author(s)
      藤内ら
    • Organizer
      日本生物環境工学会2012年東京大会
    • Place of Presentation
      東京大学(東京)
    • Related Report
      2012 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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