Environmental Control for Rapid Production of an Influenza VaccineAntigen using Plants
Project/Area Number |
23780255
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Agricultural environmental engineering
|
Research Institution | The University of Tokyo |
Principal Investigator |
MATSUDA Ryo 東京大学, 大学院・農学生命科学研究科, 講師 (20547228)
|
Project Period (FY) |
2011 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
|
Keywords | 一過性遺伝子発現 / ウイルスベクター / インフルエンザワクチン / 環境調節 / ベンサミアナタバコ / ヘマグルチニン / 気温 / 光合成有効光量子束密度 / 一過的遺伝子発現 / 物理環境調節 / 植物利用型医薬用物質生産 |
Research Abstract |
Effects of plant growing conditions such as physical environment on the level of recombinant influenza hemagglutinin accumulation were investigated in a viral vector-based transient gene expression system. We found that air temperature post viral-vector inoculation was an important environmental variable for enhancing hemagglutinin productivity. We also suggested that vacuum infiltration of plant aerial parts can be improved for increasing the efficiency of vector inoculation.
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Report
(3 results)
Research Products
(5 results)