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Elucidation of modulation of crosstalk between enteric nervous system and intestinal epithelium by the stimulation with lactic acid bacteria

Research Project

Project/Area Number 23780274
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Zootechnical science/Grassland science
Research InstitutionNational Agriculture and Food Research Organization

Principal Investigator

TOHNO Masanori  独立行政法人農業・食品産業技術総合研究機構, 畜産草地研究所・家畜飼養技術研究領 域, 研究員 (50547718)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords乳酸菌 / プロバイオティクス / 消化管生理 / 腸管神経
Research Abstract

Disruption of the intestinal microflola balance and the function of enteric nervous system are caused by feeling stress in human and livestock. The purpose of this study was to elucidate the modulation of crosstalk between enteric nervous system and intestinal epithelium by the stimulation with lactic acid bacteria. We found that low-molecular peptidoglycan fragments, muramyl dipeptide, had an ability to modulate the function of enteric nervous system. The present study could help in the development of new physiologically functional probiotic foods, feeds and drugs contributing to modulation of enteric nervous system.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (8 results)

All 2013 2011 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (2 results) Remarks (1 results)

  • [Journal Article] Weissella oryzae sp. nov., isolated from fermented rice grains2013

    • Author(s)
      M. Tohno, M. Kitahara, H. Inoue, R.Uegaki, T. Irisawa, M. Ohkuma, K. Tajima
    • Journal Title

      International Journal of Systematic and Evolutionary Microbiology

      Volume: 63 Pages: 1417-1420

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Immunobiotic Lactobacillus strains augment NLRP3 expression in newborn and adult porcine gut- associated lymphoid tissues2011

    • Author(s)
      M. Tohno, T. Shimosato, H. Aso, H.Kitazawa
    • Journal Title

      Veterinary Immunology and Immunopathology

      Volume: 144 Pages: 410-416

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Immunobiotic Lactobacillus strains augment NLRP3 expression in newborn and adult porcine gut-associated lymphoid tissues2011

    • Author(s)
      Tohno, M., H.Aso, H.Kitazawa, et al
    • Journal Title

      Vet.Immunol.Immunopathol.

      Volume: 144 Issue: 3-4 Pages: 410-416

    • DOI

      10.1016/j.vetimm.2011.09.010

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Lactobacillus oryzae sp. nov., isolated from fermented rice grain (Oryza sativa L. subsp. japonica)

    • Author(s)
      M. Tohno, M. Kitahara, T. Irisawa, H.Inoue, R. Uegaki, M. Ohkuma, K. Tajima
    • Journal Title

      International Journal of Systematic and Evolutionary Microbiology

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lactobacillus hokkaidonensis sp. nov., isolated from timothy grass (Phleum pratense L.) silage in Hokkaido, Japan

    • Author(s)
      M. Tohno, M. Kitahara, R. Uegaki, T.Irisawa, M. Ohkuma, K. Tajima
    • Journal Title

      International Journal of Systematic and Evolutionary Microbiology

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Presentation] 腸管免疫系におけるイムノバイオティック乳酸菌によるNLRP3受容体の発現増強2011

    • Author(s)
      遠野雅徳、下里剛士、麻生久、北澤春樹
    • Organizer
      日本畜産学会第114回大会
    • Place of Presentation
      青森県
    • Year and Date
      2011-07-28
    • Related Report
      2012 Final Research Report
  • [Presentation] 腸管免疫系におけるイムノバイオティック乳酸菌によるNLRP3受容体の発現増強2011

    • Author(s)
      遠野 雅徳、下里 剛士、麻生 久、北澤 春樹
    • Organizer
      日本畜産学会第114回大会
    • Place of Presentation
      北里大学獣医学部(青森県)
    • Related Report
      2011 Research-status Report
  • [Remarks]

    • URL

      http://www.naro.affrc.go.jp/nilgs/

    • Related Report
      2012 Final Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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