| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Research Abstract |
In this research, we found that transcription factor-base reprogramming require strong Oct4 binding to the promoter region. We succeed strong binding Oct4 promoter region and radical acceleration of mouse iPS cell production by chimeric Oct4 with transactivation domain from MyoD and VP16. However, oocyte-base reprogramming by somatic cell nuclear transfer could not accelerated by chimeric Oct4 injection into ooplasm.
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