The mechanism for the hypoglycaemia induced suppression of gonadal function in the pituitary gland
Project/Area Number |
23780282
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Applied animal science
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Research Institution | Kinki University |
Principal Investigator |
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Project Period (FY) |
2011 – 2013
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Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 低血糖 / LH / FSH / AMPK / 下垂体 / 性腺刺激ホルモン産生細胞 / 性腺機能 / 低栄養 / ゴナドトロフ / 性腺刺激ホルモン / AICAR / 栄養 / 血糖値 / 生殖 / GnRH / グルコース |
Research Abstract |
In the present study, we observed the restriction of glucose availability induced the transcriptional suppression of luteinizing hormone beta subunit (LHbeta) and follicle-stimulating hormone beta subunit (FHSbeta) genes via AMP-activated protein kinase (AMPK) signaling pathway in the gonadotropic LbetaT2 cell line. The result suggests a possibility that gonadotrophs of the pituitary gland participate in nutritional disorders inducing reproductive dysfunction in many mammalian species from cattle to humans.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Redundancy in Kiss1 Expression Safeguards Reproduction in the Mouse2013
Author(s)
S. M. Popa, R. M. Moriyama, C. S. Caligioni, C. M. Cho, T. L. Concepcion, A. E. Oakley, I. H. Lee, E. Sanz, P. S. Amieux, A. Caraty, R. D. Palmiter, V. M. Navarro, Y.-M. Chan, S. B. Seminara, D. K. Clifton, A. Steiner
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Journal Title
Endocrinology
Volume: Vol. 154, Issue 8
Pages: 2784-2794
Related Report
Peer Reviewed
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[Journal Article] Redundancy in Kiss1 Expression Safeguards Reproduction in the Mouse.2013
Author(s)
Simina M. Popa, Ryutaro M. Moriyama, Claudia S. Caligioni, Caroline M. Cho, Tessa L. Concepcion, Amy E. Oakley, In Hae Lee, Elisenda Sanz, Paul S. Amieux, Alain Caraty, Richard D. Palmiter, Victor M. Navarro, Yee-Ming Chan, Stephanie B. Seminara, Donald K. Clifton, Robert A. Steiner
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Journal Title
Endocrinology
Volume: 154(8)
Issue: 8
Pages: 2784-2794
DOI
Related Report
Peer Reviewed
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[Presentation] A Peripherally-Restricted Kappa Agonist (PRKA) as a Novel Approach to the Treatment of Menopausal Hot Flashes2013
Author(s)
A. E. Oakley, R. Million, L. W. Organick, R. Moriyama, K. E. Manbeck, J. R. Levin, D. Reed, C. Chavkin, D. K. Clifton, R.t A. Steiner
Organizer
Endocrine Society's 95^<th> Annual Meeting & Expo (ENDO2013)
Place of Presentation
San Francisco, California
Year and Date
2013-06-17
Related Report
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[Presentation] Fertility in the Presence of Minute Levels of Kisspeptin2012
Author(s)
S. M. Popa, R. M. Moriyama, C. Cho, T. L. Concepcion, A. E. Oakley, I. H. Lee, E. Sanz, C. S. Caligioni, Yee-Ming Chan, S. B. Seminara, V. M. Navarro, D. K Clifton, R. A. Steiner
Organizer
2^<nd> World Conference of Kisspeptin signaling in the brain
Place of Presentation
University of Tokyo, Tokyo
Year and Date
2012-11-07
Related Report
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[Presentation] Fertility in the Presence of Minute Levels of Kisspeptin.2012
Author(s)
S.M. Popa, R.M. Moriyama, C. Cho, T.L. Concepcion, A.E. Oakley, I.H. Lee, E. Sanz, C.S. Caligioni, Yee-Ming Chan, S.B. Seminara, V.M. Navarro, D.K Clifton, R.A. Steiner
Organizer
2nd World Conference of Kisspeptin signaling in the brain
Place of Presentation
University of Tokyo, Tokyo
Related Report
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