| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Research Abstract |
Endothelin-1 (ET-1) is known as a most potent vasoconstrictor and participates in feto-placental growth and development during pregnancy. The aim of this study was to investigate physiological role of ET-1 in the regulation of placental function during pregnancy in cattle. The results of present study demonstrate that ET-1 is locally produced in bovine placenta and secreted into maternal circulation during pregnancy. In addition, ET-1 interacts with various vasoactive peptides, angiogenic factors and placental hormones within bovine placenta. These findings suggest a crucial role of ET-1 in the regulation of placental function and involvement of vasoactive substances including ET-1 on maintenance of bovine pregnancy.
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