Research for a mechanism for generation of GnRH pulse regulated by neural activity of kisspeptin neurons in the arcuate nucleus
| Project/Area Number |
23780285
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied animal science
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| Research Institution | National Institute of Agrobiological Sciences |
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Principal Investigator |
WAKABAYASHI Yoshihiro 独立行政法人農業生物資源研究所, 動物生産生理機能研究ユニット, 主任研究員 (00510695)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | キスペプチン / 弓状核 / NKB / neurokinin B (NKB) / Dynorphin / パルス状分泌 |
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| Research Abstract |
Kisspeptin neurons in the arcuate nucleus (ARC) might regulate pulsatile secretion of GnRH/LH. Neural activity of the majority of these neurons might burst simultaneously, however a mechanism for this phenomenon still remains unclear. In this study, we addressed how mechanism controls the simultaneous burst of majority of the ARC kisspeptin neurons. The ARC kisspeptin neurons have neural network each other by their fibers in the contralateral as well as ipsilateral side. And recording of neural activity revealed that neural activity of ARC kisspeptin neurons from both side were synchronized. These results suggest that synchronized neural activity of majority of ARC kisspeptin neurons might be controlled by neural network using their fibers.
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Report
(3 results)
Research Products
(20 results)
