| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
The aim of this study was to clarify postnatal changes in neural control of esophageal motility and characters of esophageal muscles in rats. The main findings are: (1) the vagus nerves directly innervate both the striated and smooth muscles and control their motility in the early neonatal period, (2) striated muscle reactions gradually enlarge with age in days, whereas smooth muscle responses decline during the first week after birth, (3) sensitivity of acetylcholine to the esophageal striated muscle decrease with age in days, (4) the gamma-subunit of nicotinic acetylcholine receptors and gap junction are expressed in the neonatal esophagus but not the adult esophagus. These specific features might contribute to appropriate regulation of esophageal motility in neonatal animals.
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