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Neural mechanism mediating the mating-induced ovulation in the musk shrew, a reflex ovulator

Research Project

Project/Area Number 23780292
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Basic veterinary science/Basic zootechnical science
Research InstitutionNagoya University

Principal Investigator

INOUE Naoko  名古屋大学, 生命農学研究科, 助教 (90377789)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywordsスンクス / 交尾排卵 / 交尾刺激 / キスペプチン / 性腺刺激ホルモン放出ホルモン / 神経 / GnRH / LH / 嗅覚刺激
Research Abstract

The present study suggests that the mating stimulus activates kisspeptin neurons in the preoptic area (POA), and then stimulates gonadotropin-releasing hormone (GnRH) release to induce ovulation in the musk shrew, a reflex ovulator. The gracile nucleus, the sensory spinal nerve terminal, and the solitary nucleus, the sensory vagus nerve terminal, may mediate the mating stimulus to the POA kisspeptin neurons in the musk shrew.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (26 results)

All 2014 2013 2012 2011

All Journal Article (7 results) (of which Peer Reviewed: 3 results) Presentation (19 results) (of which Invited: 1 results)

  • [Journal Article] Epigenetic regulation of Kiss1 gene expression mediating estrogen-positive feedback action in the mouse brain2012

    • Author(s)
      Tomikawa J, Uenoyama Y, Ozawa M, Fukanuma T, Takase K, Goto T, Abe H, Ieda N, Minabe S, Deura C, Inoue N, Sanbo M, Tomita K, Hirabayashi M, Tanaka S, Imamura T, Okamura H, Maeda K, Tsukamura H
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 109

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] キスペプチンと生殖腺刺激ホルモン放出ホルモン(GnRH)分泌2012

    • Author(s)
      井上直子,束村博子,前多敬一郎
    • Journal Title

      Clinical Neuroscience

      Volume: 30巻 Pages: 220-222

    • Related Report
      2013 Final Research Report
  • [Journal Article] キスペプチンと生殖腺刺激ホルモン放出ホルモン(GnRH)分泌2012

    • Author(s)
      井上直子、束村博子、前多敬一郎
    • Journal Title

      Clinical Neuroscience

      Volume: 30 Pages: 220-222

    • Related Report
      2011 Research-status Report
  • [Journal Article] 卵胞発育の中枢制御機構2011

    • Author(s)
      井上直子,上野山賀久,大蔵聡,束村博子,前多敬一郎
    • Journal Title

      Hormone Frontier in Gynecology

      Volume: 18巻 Pages: 391-394

    • Related Report
      2013 Final Research Report
  • [Journal Article] Kisspeptin neurons mediate reflex ovulation in the musk shrew (Suncus murinus)2011

    • Author(s)
      Inoue N, Sasagawa K, Ikai K, Sasaki Y, Tomikawa J, Oishi S, Fujii N, Uenoyama Y, Ohmori Y, Yamamoto N, Hondo E, Maeda K, Tsukamura H
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 108 Pages: 17527-17532

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Kisspeptin neurons mediate reflex ovulation in the musk shrew (Suncus murinus).2011

    • Author(s)
      Inoue, N. Sasagawa, K. Ikai, K. Sasaki, Y. Tomikawa, J. Oishi, S. Fujii, N. Uenoyama, Y. Ohmori, Y. Yamamoto, N. Hondo, E. Maeda, K. Tsukamura, H.
    • Journal Title

      Proc Natl Acad Sci U S A.

      Volume: 108 Issue: 42 Pages: 17527-17532

    • DOI

      10.1073/pnas.1113035108

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 卵胞発育の中枢制御機構2011

    • Author(s)
      井上直子、上野山賀久、大蔵聡、束村博子、前多敬一郎
    • Journal Title

      Hormone Frontier in Gynecology

      Volume: 18 Pages: 391-394

    • Related Report
      2011 Research-status Report
  • [Presentation] スンクスにおける交尾排卵制御機構2014

    • Author(s)
      井上直子
    • Organizer
      第8回スンクス研究会
    • Place of Presentation
      自治医科大学
    • Year and Date
      2014-03-26
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] スンクスにおける生殖制御機構2013

    • Author(s)
      井上直子
    • Organizer
      スンクスを用いた脳-末梢連関研究
    • Place of Presentation
      埼玉大学
    • Year and Date
      2013-02-16
    • Related Report
      2013 Final Research Report
  • [Presentation] 遺伝子改変スンクス作製に向けた胚移植法の確立2013

    • Author(s)
      堀田章徳、山本彩子、後藤哲平、平林真澄、前多敬一郎、大森保成、本道栄一、井上直子
    • Organizer
      日本繁殖生物学会第106回大会
    • Place of Presentation
      東京農工大学
    • Related Report
      2013 Final Research Report
  • [Presentation] 交尾刺激を伝達する神経回路の解明2013

    • Author(s)
      大久保紫織、大森保成、山本直之、本道栄一、井上直子
    • Organizer
      日本繁殖生物学会第106回大会
    • Place of Presentation
      東京農工大学
    • Related Report
      2013 Final Research Report
  • [Presentation] 交尾刺激を伝達する神経回路の解明2013

    • Author(s)
      大久保紫織, 大森保成, 山本直之, 本道栄一, 井上直子
    • Organizer
      第106回日本繁殖生物学会大会
    • Place of Presentation
      東京農工大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] 遺伝子改変スンクス作製に向けた胚移植法の確立2013

    • Author(s)
      堀田章徳, 山本彩子, 後藤哲平, 平林真澄, 前多敬一郎, 大森保成, 本道栄一, 井上直子
    • Organizer
      第106回日本繁殖生物学会大会
    • Place of Presentation
      東京農工大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] スンクスにおける生殖制御機構2013

    • Author(s)
      井上直子
    • Organizer
      スンクスを用いた脳ー末梢連関研究シンポジウム
    • Place of Presentation
      埼玉大学
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Analysis of promoter region of gonadotropin-releasing hormone 2 gene in the musk shrew (Suncus murinus)2012

    • Author(s)
      Hotta A, Hondo E, Ohmori Y, Inoue N
    • Organizer
      The 4th Congress of Asian Association of Veterinary Anatomists
    • Place of Presentation
      Thailand, Phuket
    • Related Report
      2013 Final Research Report
  • [Presentation] Elucidation of neuronal circuits that transmit the mating stimulus in the musk shrew (Suncus murinus)2012

    • Author(s)
      Ohkubo S, Hondo E, Ohmori Y, Inoue N
    • Organizer
      The 4th Congress of Asian Association of Veterinary Anatomists
    • Place of Presentation
      Thailand, Phuket
    • Related Report
      2013 Final Research Report
  • [Presentation] Elucidation of neuronal corcuits that transmit the mating stimulus in the musk shrew (Suncus murinus).2012

    • Author(s)
      Ohkubo S, Hondo E, Ohmori Y and Inoue N.
    • Organizer
      The 4th Congress of Asian Association of Veterinary Anatomists
    • Place of Presentation
      タイ王国、プーケット
    • Related Report
      2012 Research-status Report
  • [Presentation] Analysis of the promoter region of gonadotropin-releasing hormone II gene in the musk shrew (Suncus murinus).2012

    • Author(s)
      Hotta A, Hondo E, Ohmori Y and Inoue N.
    • Organizer
      The 4th Congress of Asian Association of Veterinary Anatomists
    • Place of Presentation
      タイ王国、プーケット
    • Related Report
      2012 Research-status Report
  • [Presentation] Involvement of kisspeptin neurons in reflex ovulation in the musk shrew (Suncus murinus)2011

    • Author(s)
      Inoue N, Sasagawa K, Uenoyama Y, Hondo E, Maeda K, Tsukamura H
    • Organizer
      The 2nd World Congress on Reproductive Biology (WCRB)
    • Place of Presentation
      Australia, Cairns
    • Year and Date
      2011-10-11
    • Related Report
      2013 Final Research Report
  • [Presentation] 井上直子、スンクスの脳におけるGnRH2ニューロンの局在2011

    • Author(s)
      猪飼耕太郎、大森保成、本道栄一
    • Organizer
      東海実験動物研究会
    • Place of Presentation
      名古屋市立大学
    • Year and Date
      2011-07-23
    • Related Report
      2013 Final Research Report
  • [Presentation] スンクスにおけるGnRH2ニューロンの免疫組織化学的解析2011

    • Author(s)
      猪飼耕太郎、長谷川喜久、山本直之、大森保成、本道栄一、井上直子
    • Organizer
      日本繁殖生物学会第104回大会
    • Place of Presentation
      盛岡
    • Related Report
      2013 Final Research Report
  • [Presentation] スンクスの交尾排卵制御機構におけるキスペプチンニューロンの関与2011

    • Author(s)
      笹川佳倫、猪飼耕太郎、上野山賀久、本道栄一、前多敬一郎、束村博子、井上直子
    • Organizer
      日本繁殖生物学会第104回大会
    • Place of Presentation
      盛岡
    • Related Report
      2013 Final Research Report
  • [Presentation] スンクスの脳におけるGnRH2ニューロンの局在2011

    • Author(s)
      猪飼耕太郎、大森保成、本道栄一、井上直子
    • Organizer
      東海実験動物研究会
    • Place of Presentation
      名古屋市立大学(名古屋市)
    • Related Report
      2011 Research-status Report
  • [Presentation] スンクスの交尾排卵制御機構におけるキスペプチンニューロンの関与2011

    • Author(s)
      笹川佳倫、猪飼耕太郎、上野山賀久、本道栄一、前多敬一郎、束村博子、井上直子
    • Organizer
      日本繁殖生物学会
    • Place of Presentation
      いわて県民情報交流センター・アイーナ(盛岡市)
    • Related Report
      2011 Research-status Report
  • [Presentation] スンクスにおけるGnRH2ニューロンの免疫組織化学的解析2011

    • Author(s)
      猪飼耕太郎、長谷川喜久、山本直之、大森保成、本道栄一、井上直子
    • Organizer
      日本繁殖生物学会
    • Place of Presentation
      いわて県民情報交流センター・アイーナ(盛岡市)
    • Related Report
      2011 Research-status Report
  • [Presentation] Involvement of kisspeptin neurons in reflex ovulation in the Musk Shrew (Suncus murinus)2011

    • Author(s)
      Naoko Inoue, Karin Sasagawa, Yoshihisa Uenoyama, Eiichi Hondo, Kei-ichiro Maeda and Hiroko Tsukamura
    • Organizer
      The 2nd World Congress on Reproductive Biology (WCRB)
    • Place of Presentation
      Cairns Convention Centre(オーストラリア、ケアンズ)
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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