Elucidation of anti-obesity mechanism by new energy metabolism regulatory factor
Project/Area Number |
23780296
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Basic veterinary science/Basic zootechnical science
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Research Institution | University of Miyazaki |
Principal Investigator |
AKIEDA Sayaka 宮崎大学, フロンティア科学実験総合センター, 助教 (20549076)
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Project Period (FY) |
2011 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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Keywords | マクロファージ / 脂肪細胞 / 肥満 / 高脂肪食耐性動物 / エネルギー代謝調節 / 国際情報交流 |
Research Abstract |
A high-fat diet (HFD) is a well-known contributing factor in the development of obesity. Most rats fed HFDs become obese. Those that avoid obesity when fed HFDs are considered diet resistant (DR). We performed a microarray screen to identify genes specific to the mesenteric fat of DR rats and revealed high expression of guanylin and guanylyl cyclase C (GC-C) in some subjects. Our histologic studies revealed that the cellular source of guanylin and GC-C is macrophages. Therefore, we developed double-transgenic (Tg) rats overexpressing guanylin and GC-C inmacrophages and found that they were resistant to the effects of HFDs. Our results suggest that the macrophagic guanylin-GC-C system contributes to the altered expression of genes involved in lipid metabolism, leading to resistance to obesity.
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Report
(3 results)
Research Products
(46 results)
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[Journal Article] Involvement of guanylin and GC-C in rat mesenteric macrophages in resistance to high-fat diet.2013
Author(s)
Akieda-Asai S, Sugiyama M, Miyazawa T, Koda S, Okano I, Senba K, Poleni PE, Hizukuri Y, Okamoto A, Yamahara K, Mutoh E, Aoyama F, Sawaguchi A, Furuya M, Miyazato M, Kangawa K, Date Y
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Journal Title
Journal of Lipid Research
Volume: 54
Issue: 1
Pages: 85-96
DOI
Related Report
Peer Reviewed
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[Presentation] A new bioactive peptide and its receptor cascades prevent the accumulation of lipid droplets2011
Author(s)
Akieda-AsaiS, Sugiyama M, Miyazawa T, Koda S, Okano I, Senba K, Poleni PE, Hizukuri Y, Okamoto A, Mutoh E, Furuya M, Miyazato M, Kangawa K, Date Y
Organizer
Keystone Symposia (Lipid Biology and Lipotoxicity)
Place of Presentation
Killarney (Ireland)
Related Report
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[Presentation] A new bioactive peptide and its receptor cascades prevent the accumulation of lipid droplets2011
Author(s)
Akieda-Asai S, Sugiyama M, Miyazawa T, Koda S, Okano I, Senba K, Poleni PE, Hizukuri Y, Okamoto A, Mutoh E, Furuya M, Miyazato M, Kangawa K, Date Y
Organizer
Keystone Symposia (Lipid Biology and Lipotoxicity)
Place of Presentation
INEC-Ireland's National Events & Conference Centre,Killarney (Ireland)
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[Presentation] 肥満抵抗性ラットの解析.
Author(s)
伊達紫, 秋枝さやか
Organizer
第9回宮崎サイエンスキャンプ
Place of Presentation
宮崎シーガイアコンベンションセンター(宮崎県)
Related Report
Invited
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