Discover ofnovel bioactive peptide and application-using model organism-

• Project/Area Number: 23780297
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Basic veterinary science/Basic zootechnical science
• Research Institution: University of Miyazaki
• Principal Investigator: IDA Takanori 宮崎大学, IR 推進機構, 助教 (00381088)
• Co-Investigator(Renkei-kenkyūsha): MURAKAMI Noboru 宮崎大学, 農学部・獣医学科, 教授 (80150192) ; SANO Hiroko お茶の水女子大学, お茶大アカデミック プロダクション, 特任助教 (90506908)
• Research Collaborator: TOMINAGA Hatsumi 宮崎大学, IR 推進機構, 技術職員
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 新規生理活性ペプチド / オーファンGPCR / ショウジョウバエ / 摂食行動 / オーファン受容体 / 生理活性ペプチド / モデル生物

Research Abstract

It is very important to discover a novel bioactive peptide to the orphan receptor. I have discovered 5 novel bioactive peptides in Drosophila, a useful model organism. I tried application to mammal, insect and crustacean. Therefore, I observed that dRYamide modulate feeding behavior and cardiovascular system in mouse and promote hiding sand behavior. CCHamide stimulate feeding behavior in insect.

Research Products

• [Journal Article] Isolation of the bioactive peptides CCHamide-1 and CCHamide-2 from Drosophila and their putative role in appetite regulation as ligands for G protein-coupled receptors (2012)
  • Author(s): Ida T, Takahashi T, Tominaga H, Sato T, Sano H, Kume K, Ozaki M, Hiraguchi T, Shiotani H, Terajima S, Nakamura Y, Mori K, Yoshida M, Kato J, Murakami N, Miyazato M, Kangawa K, Kojima M
  • Journal Title: Front Endocrinol (Lausanne) Volume: 3 Pages: 177-177
  • DOI: 10.3389/fendo.2012.00177
  • Peer Reviewed
• [Journal Article] Different distribution of neuromedin S and its mRNA in the rat brain: NMS peptide is present not only in the hypothalamus as the mRNA, but also in the brainstem (2012)
  • Author(s): Mori M, Mori K, Ida T, Sato T, Kojima M, Miyazato M, Kangawa K
  • Journal Title: Front Endocrinol (Lausanne) Volume: 3 Pages: 152-152
  • DOI: 10.3389/fendo.2012.00152
  • Peer Reviewed
• [Journal Article] The role of neuromedin U during inflammatory response in the common carp (2012)
  • Author(s): Kono T, Hamasuna S, Korenaga H, Iizasa T, Nagamine R, Ida T, Sakai M
  • Journal Title: Fish Shellfish Immunol Volume: 32 Issue: 1 Pages: 151-160
  • DOI: 10.1016/j.fsi.2011.11.004
  • Peer Reviewed
• [Journal Article] Variety of Acyl Modificationsin Mammalian Ghrelins (2012)
  • Author(s): Ida T
  • Journal Title: Methods in Enzymology Volume: 514 Pages: 63-73
  • DOI: 10.1016/b978-0-12-381272-8.00004-0
• [Journal Article] Identification of the endogenous cysteine-rich peptide trissin, ligand for an orphan G-protein-coupled receptor in Drosophila (2011)
  • Author(s): Ida T, Takahashi T, Tominaga H, Sato T, Kume K, Yoshizawa-Kumagae K, Nishio H, Kato J, Murakami N, Miyazato M, Kangawa K, Kojima M
  • Journal Title: Biochem Biophys Res Commun Volume: 414 Issue: 1 Pages: 44-48
  • DOI: 10.1016/j.bbrc.2011.09.018
  • Peer Reviewed
• [Journal Article] Identification of the novel bioactive peptides dRYamide-1 and dRYamide-2, ligands for a neuropeptide Y-like receptor in Drosophila (2011)
  • Author(s): Ida T, Takahashi T, Tominaga H, Sato T, Kume K, Ozak Mi, Hiraguchi T, Maeda T, Shiotani H, Terajima S, Sano H, Mori K, Yoshida M, Miyazato M, Kato J, Murakami N, Kangawa K, Kojima M
  • Journal Title: Biochem Biophys Res Commun Volume: 410 Issue: 4 Pages: 872-877
  • DOI: 10.1016/j.bbrc.2011.06.081
  • Peer Reviewed
• [Journal Article] Continuous Antagonism of the Ghrelin Receptor Results in Early Induction of Salt-Sensitive Hypertension (2011)
  • Author(s): Takahiro Sato, Yoshiki Nakashima, Yuki Nakamura, Takanori Ida, Masayasu Kojima
  • Journal Title: J. Mol. Neurosci Volume: 43巻 Issue: 2 Pages: 193-199
  • DOI: 10.1007/s12031-010-9414-1
  • Peer Reviewed
• [Presentation] ショウジョウバエ新規生理活性ペプチドの発見と応用 (2012)
  • Author(s): 井田隆徳、富永初美、岩元絵里、粂和彦、佐藤貴弘、佐野浩子、平口鉄太郎、尾崎まみこ、宮里幹也、寒川賢治、児島将康
  • Organizer: 第37回日本比較内分泌学会大会
  • Place of Presentation: 福井
  • Year and Date: 2012-11-30
• [Presentation] 家畜グレリンの精製と応用 (2012)
  • Author(s): 富永初美、岩元絵里、井田隆徳、保田昌宏、桑野睦敏、児島将康、宮里幹也、寒川賢治、加藤丈司
  • Organizer: 第37回日本比較内分泌学会大会
  • Place of Presentation: 福井
  • Year and Date: 2012-11-30
• [Presentation] ショウジョウバエ新規生理活性ペプチドの発見と応用 (2012)
  • Author(s): 井田隆徳
  • Organizer: 第37回日本比較内分泌学会大会
  • Place of Presentation: 福井市
• [Presentation] 家畜グレリンの精製と応用 (2012)
  • Author(s): 富永初美
  • Organizer: 第37回日本比較内分泌学会大会
  • Place of Presentation: 福井市
• [Presentation] モデル生物を利用した新規生理活性ペプチドの探索 (2011)
  • Author(s): 井田隆徳、佐藤貴弘、児島将康
  • Organizer: 第151回日本獣医学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2011-09-20
• [Presentation] 新規生理活性ペプチドの探索-モデル生物を利用して- (2011)
  • Author(s): 井田隆徳
  • Organizer: 第5回トランスポーター研究会 九州部会
  • Place of Presentation: 宮崎
  • Year and Date: 2011-09-17
• [Presentation] ショウジョウバエ新規生理活性ペプチドの発見 (2011)
  • Author(s): 井田隆徳
  • Organizer: 第4回分子高次機能研究会
  • Place of Presentation: 熊本
  • Year and Date: 2011-08-28
• [Presentation] モデル生物を利用した新規生理活性ペプチドの探索 (2011)
  • Author(s): 井田隆徳、佐藤貴弘、児島将康
  • Organizer: 第151回日本獣医学会学術集会
  • Place of Presentation: 大阪府立大学
• [Book] ペプチド医薬の最前線 (2012)
  • Author(s): 井田隆徳、児島将康、加藤丈司
  • Publisher: シーエムシー出版
• [Book] ペプチド医薬の最前線 (2012)
  • Author(s): 井田隆徳
  • Total Pages: 5
  • Publisher: シーエムシー出版
• [Book] Methods in Enzymology (2012)
  • Author(s): Ida T
  • Total Pages: 11
  • Publisher: Elsevier Inc.
• [Remarks]
  • URL: http://www.cc.miyazaki-u.ac.jp/a0d203u/index.html
• [Remarks] 宮崎大学IR推進機構 井田研究室
  • URL: http://www.cc.miyazaki-u.ac.jp/a0d203u/index.html
• [Remarks] 宮崎大学型若手研究リーダー育成モデル
  • URL: http://www.miyazaki-u.ac.jp/ir/
• [Remarks]
  • URL: http://www.cc.miyazaki-u.ac.jp/a0d203u/index.html
• [Remarks]
  • URL: http://www.miyazaki-u.ac.jp/ir/
• [Patent(Industrial Property Rights)] ショウジョウバエ由来生理活性ペプチドdRYamide (2012)
  • Inventor(s): 井田隆徳 児島将康
  • Industrial Property Rights Holder: 宮崎大学 久留米大学
  • Filing Date: 2012-03-26
• [Patent(Industrial Property Rights)] ショウジョウバエ由来生理活性ペプチドｄＲＹａｍｉｄｅ (2011)
  • Inventor(s): 井田隆徳 児島将康
  • Industrial Property Rights Holder: 井田隆徳 児島将康
  • Industrial Property Number: 2011-085684
  • Filing Date: 2011