Involvement of MARCKS on methylmercury neurotoxicity and application as a marker for neurotoxicity
| Project/Area Number |
23780298
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Basic veterinary science/Basic zootechnical science
|
|---|
| Research Institution | Kagoshima University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | メチル水銀 / MARCKS |
|---|
| Research Abstract |
Because myristoylated alanine-rich C kinase substrate (MARCKS) plays an essential role in the differentiation and development of neuronal cells, we studied the alteration of MARCKS expression and phosphorylation in MeHg-induced neurotoxicity of neuroblastoma SH-SY5Y cells and in the rat brain. Exposure to MeHg induced a decrease in cell viability of SH-SY5Y cells, which was accompanied by an alteration of MARCKS phosphorylation and expression. In brain tissue from MeHg-treated rats, abnormal MARCKS phosphorylation was observed. The present study may indicate that alteration in MARCKS has consequences for MeHg-induced neurotoxicity.
|
Report
(4 results)
Research Products
(15 results)
-
-
-
[Journal Article] Increased expression of aquaporin-4 with methylmercury exposure in the brain of the common marmoset2012
Author(s)
Yamamoto, M., Takeya, M., Ikeshima-Kataoka, H., Yasui, M., Kawasaki, Y., Shiraishi, M., Majima, E., Shiraishi, S., Uezono, Y., Sasaki, M., Eto, K.
-
Journal Title
The Journal of Toxicological Sciences
Volume: 37
Issue: 4
Pages: 749-763
DOI
NAID
ISSN
0388-1350, 1880-3989
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
