| Project/Area Number |
23780300
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Osaka Prefecture University |
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Principal Investigator |
AZUMA Yasutaka 大阪府立大学, 生命環境科学研究科, 准教授 (50298816)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 免疫 / 炎症性腸疾患 / インターロイキン-19 / IL-19 / T細胞 / IL-4 / MPO / サイトカイン |
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| Research Abstract |
We have used TNBS-induced colitis models to examine the roles of IL-19 in colonic inflammation and thus its possible role in IBD. We show that IL-19-deficient mice are more susceptible to experimental acute colitis induced by TNBS, evaluated by body weight changes, leukocyte infiltration and epithelial cell damage. This increased susceptibility was correlated with increased production of IFN・, IL-12, IL-22, and IL-33. The finding that IL-19 drives pathogenic adaptive immune responses in the colon suggests that the selective targeting of IL-19 may be an effective therapeutic approach in the treatment of human IBD.
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