| Project/Area Number |
23780305
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied veterinary science
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| Research Institution | Hokkaido University |
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Principal Investigator |
IGARASHI Manabu 北海道大学, 人獣共通感染症リサーチセンター, 特任助教 (10374240)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | インフルエンザ / ウイルス / 計算科学 / 分子動力学 / 抗体 / 分子動力学シミュレーション / 分子間相互作用 / 抗原変異 / フラグメント分子軌道法 / 感染症 / 生体生命情報学 / 分子シミュレーション / 分子動力学計算 |
|---|
| Research Abstract |
Influenza A virus is a zoonotic pathogen that is transmitted from animals to humans. This virus has two surface glycoproteins, hemagglutinin (HA) and neuraminidase. The HA of human influenza virus is the major target of antibodies that neutralize viral infectivity. Some amino acid substitutions in the antigenic epitope on the HA could decrease the interaction between HA and antibodies, leading to generate the antigenic variants with a novel antigenic structure of HA. To understand how amino acid substitutions affect the changes of the HA antigenic structure, we computationally analyzed the three-dimensional structures of HA in complex with monoclonal antibody.
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