Development of a novel treatment to prevent bacterial infection by the inhibition of inter-bacterial signal transduction.
| Project/Area Number |
23780308
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Applied veterinary science
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
MINEMATSU Takeo 東京大学, 大学院・医学系研究科, 特任講師 (00398752)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
|---|
| Keywords | 疾病予防 / 制御 / 創傷感染 / クオラムセンシング / AHL / R蛋白質 / Quorum Sensing |
|---|
| Research Abstract |
A part of bacteria communicate mutually using AHL to detect the bacterial density in surrounding. The bacteria which recognized the higher density express the virulent genes. Therefore, we tried to develop a new prevention method of wound infection by capturing AHL outside bacteria. Although our method successfully inhibit the virulent gene expressions in vitro, it could not prevent the wound infection in the animal experiment. Further studies to identify its reason are required.
|
Report
(3 results)
Research Products
(26 results)
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] The Pseudomonas aeruginosa quorum sensing signal molecule, N-(3-oxododecanoyl) homoserine lactone, induces matrix metalloproteinase expression via MAPK/AP-1 pathway in rat fibroblast2011
Author(s)
Nakagami G, Minematsu T, Nagase T, Morohoshi T, Ikeda T, Asada M, Paes C, Sanada H
Organizer
European Wound Management Association (EWMA)
Place of Presentation
Brussels (SQUARE-BRUSSELS MEETING CENTRE), Belgium
Related Report
-
-
-
-
-
-
