Breaking immunological tolerance to canine malignant melanoma using anti-Gpnmb antibody and various antigen peptides associated with tumor.

Research Project

Project/Area Number	23780317
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Clinical veterinary science
Research Institution	Obihiro University of Agriculture and Veterinary Medicine
Principal Investigator	TOMIHARI Mizuki 帯広畜産大学, 畜産学部, 助教 (00552754)
Project Period (FY)	2011 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000) Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000) Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords	獣医学 / 臨床 / 癌 / 免疫学 / 生体分子 / 犬 / 悪性黒色腫 / 免疫療法 / 腫瘍
Research Abstract	We investigated new approachof immunological therapy for canine malignant melanoma, using anti-Gpnmb Ab and other various antigen peptides associated with tumor. The research showed that some peptides significantly activated T-lymphocytes compared to conventional method. However, the experiments with anti-Gpnmb Ab did not show notable results in T-cell activation. In the future research, we will thoroughly examine experimental conditions and intend to find more effective immunotherapy.

Report

(3 results)