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Application of exercise therapy in diabetic dogs

Research Project

Project/Area Number 23780328
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Clinical veterinary science
Research InstitutionNippon Veterinary and Life Science University

Principal Investigator

MORI AKIHIRO  日本獣医生命科学大学, 獣医学部, 助教 (60549559)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords運動療法 / 犬 / 糖尿病 / 糖尿病犬
Research Abstract

In this study, we investigated whether therapeutic exercise affects blood biochemical parameters and muscular mRNA expression in diabetic dogs. No significant difference was observed between the fasting blood glucose concentrations before and after exercise. However, the level of glycated albumin was significantly decreased after exercise. No significant difference was observed between before and after exercise in the muscular mRNA expression of insulin signaling and glucose metabolism genes including insulin receptor substrate -1 and -2. In summary, therapeutic exercise decreased glycated albumin levels and thus ameliorated glycemic control in diabetic dogs.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (8 results)

All 2014 2013 2012 2011

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (1 results)

  • [Journal Article] Changes in blood biochemical parameters and in gene expression in skeletal muscle after therapeutic exercise in diabetic dogs2014

    • Author(s)
      Saeki K, Oda H, Shono S, Ueda K, Maruyama N, Akiyama R, Onozawa E, Mori A, Sako T
    • Journal Title

      J Pet Anim Nutr

      Volume: Vol 17 Pages: 19-25

    • NAID

      130005065524

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Changes in blood biochemical parameters and in gene expression in skeletal muscle after therapeutic exercise in diabetic dogs2014

    • Author(s)
      Kaori Saeki, Hitomi Oda, Saori Shono, Kaori Ueda Natsuki Maruyama, Ran Akiyama, Eri Onozawa, Akihiro Mori, Toshinori Sako
    • Journal Title

      J. Pet Anim. Nutr

      Volume: 17 Pages: 19-25

    • NAID

      130005065524

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of glucose fluctuations between day- and night-time measured using a continuous glucosemonitoring system in diabetic dogs.2013

    • Author(s)
      Mori A, Kurishima M, Oda H, Saeki K, Arai T, Sako T.
    • Journal Title

      J Vet Med Sci

      Volume: 75 Pages: 113-117

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Potential predictive biomarkers of obesity in Burmese cats.2013

    • Author(s)
      Lee P, Mori A, Coradini M, Mori N, Sagara F, Yamamoto I, Rand JS, Arai T.
    • Journal Title

      Vet J.

      Volume: 195 Pages: 221-227

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Characterization and comparison of insulin resistance induced by Cushing Syndrome or diestrus against healthy control dogs as determined by euglycemic- hyperinsulinemic glucose clamp profile glucose infusion rate using an artificial pancreas apparatus2012

    • Author(s)
      Fukuta H, Mori A, Urumuhan N, Lee P, Oda H, Saeki K, Kurishima M, Nozawa S, Mizutani H, Mishina S, Arai T, Sako T
    • Journal Title

      J Vet Med Sci

      Volume: Vol 74 Pages: 1527-1530

    • NAID

      130001879712

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterization and comparison of insulinresistance induced by Cushing Syndrome or diestrus against healthy control dogsas determined by euglycemic- hyperinsulinemic glucose clamp profile glucoseinfusion rate using an artificial pancreas apparatus.2012

    • Author(s)
      Fukuta H, Mori A, Urumuhan N, Lee P, Oda H, Saeki K, Kurishima M, Nozawa S,Mizutani H, Mishina S, Arai T, Sako T.
    • Journal Title

      J Vet Med Sci

      Volume: 74 Pages: 1527-1530

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Evaluation of artificial pancreas technology2011

    • Author(s)
      Mori A, Lee P, Yokoyama T, et al
    • Journal Title

      J Artif Organs

      Volume: 14 Pages: 133-139

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 左向敏紀正常犬における食物摂取と運動の時間的関係性について2013

    • Author(s)
      生野佐織、佐伯香織、秋山蘭、小田民美、上田香織、丸山夏輝、森昭博
    • Organizer
      日本ペット栄養学会第15回大会
    • Year and Date
      2013-07-20
    • Related Report
      2013 Final Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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