Study on the role of ceramide kinase in the macrophage-function
| Project/Area Number |
23780344
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied molecular and cellular biology
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| Research Institution | Saga University (2013)
Hokkaido University (2011-2012) |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | ceramide / ceramide kinase / ceraide 1-phosphate / MCP-1 / obesity / diabetes / ceramide 1-phosphate / セラミド / セラミドキナーゼ / セラミド1-リン酸 |
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| Research Abstract |
Chronic and low-grade inflammation is associated with the initial steps of obesity. Ceramide kinase (CERK) is an enzyme which phosphorylates ceramide to produce ceramide 1-phosphate. Recently, evidence has emerged that CERK has a role in inflammatory signaling of immune cells. Since obesity is accompanied with chronic, low-grade inflammation, we examined whether CERK might involved using CERK-null mice. We determined that CERK deficiency suppresses diet-induced increases in body weight, and improves glucose intolerance. Furthermore, we demonstrated that CERK deficiency attenuates MCP-1/CCR2 signaling in macrophages infiltrating adipose tissue, resulting in the suppression of inflammation in adipose, which might otherwise lead to obesity and diabetes.
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] Improved High-Fat Diet-Induced Glucose Intolerance by an Oral Administration of Phytosphingosine2013
Author(s)
I. Murakami, S. Mitsutake, N. Kobayashi, J. Matsuda, A. Suzuki, T. Shigyo, Y. Igarashi,
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Journal Title
Bioscience, Biotechnology, and Biochemistry
Volume: 77
Issue: 1
Pages: 194-197
DOI
NAID
ISSN
0916-8451, 1347-6947
Related Report
Peer Reviewed
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[Journal Article] Dynamic modification of sphingomyelin in lipid microdomains controls development of obesity, fatty liver, and type 2 diabetes2011
Author(s)
S. Mitsutake, K. Zama, H. Yokota, T. Yoshida, M. Tanaka, M. Mitsui, M. Ikawa, M. Okabe, Y. Tanaka, T. Yamashita, H. Takemoto, T. Okazaki, K. Watanabe, and Y. Igarashi
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Journal Title
Journal of Biological Chemistry
Volume: 286
Pages: 28544-28555
NAID
Related Report
Peer Reviewed
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[Journal Article] QualitativeandQuantitative Cellular Glycomics of Glycosphingolipids Based on Rhodococcal Endoglycosylceramidase-assisted Glycan Cleavage, Glycoblotting-assisted Sample Preparation, and Matrix-assisted Laser Desorption Ionization Tandem Time-of-flight Mass Spectrometry Analysis2011
Author(s)
Naoki Fujitani, Yasuhiro Takegawa, Yohei Ishibashi, Kayo Araki, Jun-ichi Furukawa, Susumu Mitsutake, Yasuyuki Igarashi, Makoto Ito, Yasuro Shinohara
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Journal Title
THE JOURNAL OF BIOLOGICAL CHEMISTRY
Volume: 286
Issue: 48
Pages: 41669-41679
DOI
Related Report
Peer Reviewed
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[Presentation] Glycolipid & Sphingolipid Biology2012
Author(s)
"SMS2 is implicated as a novel regulator of lipid microdomain structure and function"Mitsutake, K. Zama, T. Yoshida, H. Takemoto, T. Okazaki, Y. Igarashi
Organizer
2012 Gordon Research Conferences
Place of Presentation
Lucca, Italy(Selected speaker)
Related Report
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