| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
In eukaryotes, heterochromatin mediates diverse biological processes including gene silencing and regulation of long-range chromatin interaction. However, the mechanism underlying heterochromatin formation is poorly understood. Our study showed that non-cording RNA in mammals involved in heterochromatin formation and the subunit of highly conserved RNA polymerase II was ubiquitinated by Cul4 ubiquitin ligase.
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