Development of Benzyne Generation using Magnesium Bisamide andIts Application to Total Synthesis of Bioactive Natural Products
| Project/Area Number |
23790004
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Chemical pharmacy
|
|---|
| Research Institution | Tohoku University |
|---|
Principal Investigator |
OKANO Kentaro 東北大学, 大学院・薬学研究科, 助教 (30451529)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
|---|
| Keywords | マグネシウムビスアミド / ベンザイン / ヘプタフィリン / バツェリン / ディスコ ハブディン / テレオシジン / マカルボン / マカルバミン / ダミロン / ディスコハブディン |
|---|
| Research Abstract |
A synthetic method for the construction of multi-substituted nitrogen heterocycles such as indolines and carbazoles was established based on the development of mild generation of benzyne species using magnesium bisamide. The utility of this method was demonstrated by the total synthesis of heptaphylline and batzelline family as well as by its broad scope of substrates and electrophiles used in the reaction.
|
Report
(3 results)
Research Products
(37 results)
