Synthetic study of highly oxygenated diterpenes based on the bridgehead radical reaction
Project/Area Number |
23790005
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Chemical pharmacy
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Research Institution | The University of Tokyo |
Principal Investigator |
URABE Daisuke 東京大学, 大学院・薬学系研究科, 助教 (80503515)
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Project Period (FY) |
2011 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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Keywords | 全合成 / ラジカル反応 / 天然物 / 生理活性物質 / テルペン / 有機化学 / 有機合成化学 / テルペノイド / ラジカル / 橋頭位 / セレニド / バートンエステル / 炭素-炭素結合 |
Research Abstract |
The C-C bond formation utilizing an alkoxy bridgehead carbon radical was developed. The high reactivity of the radical species realized the congested C-C bond formation to connect oxygenated carbocycles by two- and three-component reactions. Based on the strategy, the5/7/6-fused carbocycles of crotophorbolone, a tigliane diterpene, was successfully assembled in a stereoselective fashion.
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Report
(3 results)
Research Products
(53 results)
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[Journal Article] Identification and structure determination of a novel anti-inflammatory mediator resolvin E3 : 17, 18-dihydroxy-eicosapentaenoic acid.2012
Author(s)
Isobe Y, * Arita M, Matsueda S, Iwamoto R, Fujihara T, Nakanishi H, Taguchi R, Masuda K, Sasaki K, Urabe D, Inoue M, Arai H
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Journal Title
J. Biol. Chem
Volume: 287
Issue: 13
Pages: 10525-10534
DOI
Related Report
Peer Reviewed
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