Syntheses of novel amino acids and natural product derived from amino acid by using memory of chirality
| Project/Area Number |
23790010
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 合成化学 / 不斉記憶 / 天然物合成 / ハイブリッド型アミノ酸 / 不斉記憶型反応 / 不斉合成 / 全合成 / 非天然アミノ酸 / 天然物 |
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| Research Abstract |
Development of asymmetric intra- and intermolecular conjugate addition reaction via C-N axially chiral enolate intermediates were achieved. Multisubstituted β-lactams were prepared by using asymmetric intramolecular conjugate addition reaction. β-Lactams were converted into novel hybrid amino acid derivatives consisting of aspartic acid-glutamic acid. On the other hand, total synthesis of manzacidin A was completed by using intermolecular conjugate addition reaction.
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Report
(3 results)
Research Products
(37 results)
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[Journal Article] Protonation-Assisted Conjugate Addition of Enolate: Asymmetric Synthesis of Multisubstituted-β-Lactams from α-Amino Acids via Memory of Chirality2012
Author(s)
Yoshimura, T; Takuwa, M.; Tomohara, K.; Uyama, M.; Hayashi, K.; Yang, P.; Hyakutake, R.; Sasamori, T.; Tokitoh, N.; Kawabata, T.
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Journal Title
Chem. E. J.
Volume: 18
Issue: 48
Pages: 15330-15336
DOI
Related Report
Peer Reviewed
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