Development of catalytic asymmetric addition reactions via direct nucleophilic activation of unactivated C-H bonds
| Project/Area Number |
23790014
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 炭素ー水素結合活性化 / 遷移金属触媒 / 不斉反応 / アルキニル化 / 環境調和型反応 / アミノ酸誘導体 / 不斉四置換炭素構築 |
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| Research Abstract |
Throughout this study, we developed direct catalytic asymmetric addition reactions via nucleophilic C-H bond activation, and we succeeded in obtaining alpha-amino acid derivatives containing chiral tetrasubstituted carbon stereocenters under proton-transfer conditions. The reactions proceed at or below room temperature, and various acid- and base-sensitive functionalities are tolerant under the reaction conditions.
We also performed detailed mechanistic analysis of the reaction and isolated catalytically active species. This active species enabled shortening reaction time and performing reactions with other less-reactive substrates to provide alpha-amino acid derivatives containing chiral tetrasubstituted carbon stereocenters.
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Report
(4 results)
Research Products
(54 results)
