Total synthesis of biologically active compounds by using asymmetricorganocatalytic reactions
Project/Area Number |
23790024
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Chemical pharmacy
|
Research Institution | Kumamoto University |
Principal Investigator |
ISHIKAWA Hayato 熊本大学, 大学院・自然科学研究科, 准教授 (80453827)
|
Project Period (FY) |
2011 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 有機合成化学 / ドミノ反応 / ワンポット合成 / マイクロフロー合成 / 有機触媒 / 不斉反応 / アルカロイド / タミフル / リレンザ / インフルエンザ治療薬 |
Research Abstract |
Efficient total synthesis of Anti-Influenza drug oseltamivir knownas Tamiflu was accomplished. The key process of the synthesis for applied to the industrialscale, is our originally developed asymmetric organocatalytic reactions, domino reaction,one-pot process and micro-flow reactions. In addition, efficient synthetic methods forsynthesis of zanamivir known as Relenza were discovered.
|
Report
(3 results)
Research Products
(19 results)