Search for anti-aging compounds from medicinal flowers
| Project/Area Number |
23790028
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kyoto Pharmaceutical University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | メディシナルフラワー / 抗老化作用 / 伝承薬物 / メラニン生成抑制作用 / トリテルペンサポニン / ベンジルイソキノリン / 構造活性相関 / 作用メカニズム / Cananga odorata / Lawsonia inermis / アマチャ / リグナン / Camellia japonica / Prunus mume / トリテルペン配糖体 / アシル化キナ酸 / Nelumbo nucifera / アポロフィン型アルカロイド |
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| Research Abstract |
We have researched anti-aging compounds from medicinal flowers. As the results, several constituents and its derivatives (oleanane-type triterpene saponins, benzylisoquinoline alkaloids, acylated quinic acids, lignans, and flavonoids) from the flower buds or/and flowers of Camellia japonica, Nelumbo nucifera, Prunus mume, Cananga odorata, and Lawsonia inermis were found to show inhibitory effects on melanogenesis in theophylline-stimulated B16 melanoma 4A5 cells. Furthermore, the inhibitory effects of the related compounds on melanogenesis were examined and their structure-activity relationships were characterized. In addition, we clarified a part of the mechanism of actions of nuciferin, which was the main compound of the flower buds of N. nucifera, on melanogenesis.
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Report
(4 results)
Research Products
(53 results)
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[Journal Article] Alkaloid constituents from flower buds and leaves of sacred lotus (Nelumbo nucifera, Nymphaeaceae) with melanogenesis inhibitory activity in B16 melanoma cells2013
Author(s)
Seikou Nakamura, Souichi Nakashima, Genzo Tanabe, Yoshimi Oda, Nami Yokota, Katsuyoshi Fujimoto, Takahiro Matsumoto, Rika Sakuma, Tomoe Ohta, Keiko Ogawa, Shino Nishida, Hisako Miki, Hisashi Matsuda, Osamu Muraoka, Masayuki Yoshikawa
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Journal Title
Bioorg. Med. Chem
Volume: 21
Issue: 3
Pages: 779-787
DOI
Related Report
Peer Reviewed
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[Journal Article] Medicinal Flowers. XXXII. Structures of Oleanane-Type Triterpene Saponins, Perennisosides VIII, IX, X, XI, and XII, from the Flowers of Bellis perennis2011
Author(s)
Toshio Morikawa, Li Xuezheng, Eriko Nishida, Seikou Nakamura, Kiyofumi Ninomiya, Hisashi Matsuda, Makoto Hamao, Osamu Muraoka, Takao Hayakawa, Masayuki Yoshikawa
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Journal Title
Chemical and Pharmaceutical Bulletin
Volume: 59
Issue: 7
Pages: 889-895
DOI
NAID
ISSN
0009-2363, 1347-5223
Related Report
Peer Reviewed
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[Presentation] メディシナルフラワー研究 : 椿花(Camellia japonica,花部)および蓮花(Nelumbo nucifera,花部)のメラニン生成抑制成分2013
Author(s)
中村誠宏,松田久司,藤本勝好,田邉元三,中嶋聡一,松本崇宏,太田智絵,小川慶子,村岡修,吉川雅之
Organizer
第55回天然有機化合物討論会
Place of Presentation
京都市
Year and Date
2013-09-19
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