| Project/Area Number |
23790028
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kyoto Pharmaceutical University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | メディシナルフラワー / 抗老化作用 / 伝承薬物 / メラニン生成抑制作用 / トリテルペンサポニン / ベンジルイソキノリン / 構造活性相関 / 作用メカニズム / Cananga odorata / Lawsonia inermis / アマチャ / リグナン / Camellia japonica / Prunus mume / トリテルペン配糖体 / アシル化キナ酸 / Nelumbo nucifera / アポロフィン型アルカロイド |
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| Research Abstract |
We have researched anti-aging compounds from medicinal flowers. As the results, several constituents and its derivatives (oleanane-type triterpene saponins, benzylisoquinoline alkaloids, acylated quinic acids, lignans, and flavonoids) from the flower buds or/and flowers of Camellia japonica, Nelumbo nucifera, Prunus mume, Cananga odorata, and Lawsonia inermis were found to show inhibitory effects on melanogenesis in theophylline-stimulated B16 melanoma 4A5 cells. Furthermore, the inhibitory effects of the related compounds on melanogenesis were examined and their structure-activity relationships were characterized. In addition, we clarified a part of the mechanism of actions of nuciferin, which was the main compound of the flower buds of N. nucifera, on melanogenesis.
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