| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
Oxidation of an anionic species to a radical or cationic species is an important umpolung methodology for changing the reactivity of anionic intermediates, and it is potentially useful in combination with anionic cascade reactions. An addition reaction of alkenylmagnesium bromide with p-toluenesulfonyl isocyanate and consecutive oxidative cyclization with iodobenzene diacetate afforded brominated lactams in one pot. This oxidative halocyclization was also applicable to a one-pot synthesis of cyclic ether, cyclic amine, lactone, pyrazolidine using a aldehyde, imine, carbon dioxide, and azodicarboxylate, respectively.
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