Tandem bond forming reactions based on oxidative umpolung of organomeallic reagents
| Project/Area Number |
23790029
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
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| Research Institution | Doshisha Women's College of Liberal Arts |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 酸化 / 極性転換 / 多成分反応 / 複素環 |
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| Research Abstract |
Oxidation of an anionic species to a radical or cationic species is an important umpolung methodology for changing the reactivity of anionic intermediates, and it is potentially useful in combination with anionic cascade reactions. An addition reaction of alkenylmagnesium bromide with p-toluenesulfonyl isocyanate and consecutive oxidative cyclization with iodobenzene diacetate afforded brominated lactams in one pot. This oxidative halocyclization was also applicable to a one-pot synthesis of cyclic ether, cyclic amine, lactone, pyrazolidine using a aldehyde, imine, carbon dioxide, and azodicarboxylate, respectively.
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Report
(5 results)
Research Products
(40 results)
