Novel synthesis of biaryls via metal-free cross-coupling reaction and its application
| Project/Area Number |
23790030
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
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| Research Institution | Ritsumeikan University |
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Principal Investigator |
MORIMOTO Koji 立命館大学, 立命館グローバル・イノベー ション研究機構, ポストドクトラルフェロ (10543952)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 有機合成化学 / 芳香族 / 超原子価ヨウ素 / 機能性有用化合物 / クロスカップリング / ビアリール類 / 機能性材料 / 酸化的カップリング / ビアリール / チオフェン類 / 芳香族化合物 |
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| Research Abstract |
Biaryl compounds are versatile building blocks in the synthesis of natural products, pharmaceuticals, agricultural chemicals and π-conjugated organic materials. Therefore, the development of convenient cross-coupling reaction for giving biaryls is one of the important subjects in organic chemistry.Recently, we have developed a new synthetic method that enables metal-free regioselective oxidative coupling of 3-substituted thiphenes using hypervalent iodine(III) reagents. I have applied our coupling reaction of thiphenes to the synthesis of thiophene organic dyes as MK-2. Futher study for the oxidative coupling reaction, we also developed a metal-free direct synthesis of the discotic liquid crystal hexahydroxytriphenylene (HHTP) using hypervalent iodine reagent.
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Report
(3 results)
Research Products
(40 results)
