The development of nucleophilic addition to α-position of ketones by using N-alkoxyenamines and its application to asymmetric reactions
| Project/Area Number |
23790032
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kobe Pharmaceutical University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 有機化学 / 極性転換 / 窒素-酸素結合 / エナミン / 極性転換反応 / ヘテロアリール化 / アルデヒド |
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| Research Abstract |
The compounds bearing hetero atom-hetero atom bonds such as N-O bond has very interesting reactivity. We have developed the a-heteroarylation of ketones and a-arylation allylation reaction of aldehyde by using the Umpolung reaction of N-alkoxyenamines. Furthermore, the sequential retro-ene addition readction of N-alkokyenamides has been developed.
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Report
(3 results)
Research Products
(21 results)
