| Project/Area Number |
23790034
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
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| Research Institution | Tokushima Bunri University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | カルバボラン / 不均一系触媒 / 1,3-ジエン環化反応 / リサイクル / 再利用 / 水銀トリフラート / タンデム環化反応 / カルバボラニル水銀クロライド / 銀トリフラート / トリエトキシシラン |
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| Research Abstract |
We developed a novel heterogeneous catalyst, solid supported carbaboranylmercuric triflate, with the aim of reutilizing it. This solid supported catalyst showed the remarkable reactivities for aryl allyl alcohol cyclization, cyclization of N-tosylanilinoallylic alcohols, regioselective cycloisomerization of aryl- and hetero-substituted 1,3-dienes, tandem carbocyclization, and etc. The workup of these reactions was very simple, as the catalyst was recovered by filtration of the reaction mixture through ordinary filter paper. Moreover, the recovered catalyst was reused without significant loss of activity at least 20 times. In the case of decreasing the activity of the recovered catalyst through the process of reuse, it could be reactivated via the reaction with 2N hydrochloric acid and then silver triflate.
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