| Project/Area Number |
23790036
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
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| Research Institution | Tokushima Bunri University |
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Principal Investigator |
KUBO Miwa 徳島文理大学, 薬学部, 講師 (00330754)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 神経栄養因子 / 神経幹細胞 / PC12細胞 / 神経栄養因子様活性物質 / P12細胞 / 天然物化学 / PC12 / MEB5 / 神経突起伸展促進活性 |
|---|
| Research Abstract |
As part of our continuing studies on neurotrophic-like active compounds in natural products, we investigated the chemical compounds with neurogenesis activities, resulting in the discovery of four compounds.Especially, jiadifenolide and honokiol significantly enhance neurite outgrowth in the primary cell cultures of fetal rat cortical neurons, respectively. These are worthy of note that both compounds have potential to significantly promote differentiation of multipotent neural stem cell line MEB5 cells into neurons. Furthermore, chronic treatment of phenylbutenoid dimer from Indonesian ginger enhanced hippocampal neurogenesis in dementia model OBX mice.
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