Construction and elucidating of neural stem cell differentiation control substance library
| Project/Area Number |
23790036
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
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| Research Institution | Tokushima Bunri University |
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Principal Investigator |
KUBO Miwa 徳島文理大学, 薬学部, 講師 (00330754)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 神経栄養因子 / 神経幹細胞 / PC12細胞 / 神経栄養因子様活性物質 / P12細胞 / 天然物化学 / PC12 / MEB5 / 神経突起伸展促進活性 |
|---|
| Research Abstract |
As part of our continuing studies on neurotrophic-like active compounds in natural products, we investigated the chemical compounds with neurogenesis activities, resulting in the discovery of four compounds.Especially, jiadifenolide and honokiol significantly enhance neurite outgrowth in the primary cell cultures of fetal rat cortical neurons, respectively. These are worthy of note that both compounds have potential to significantly promote differentiation of multipotent neural stem cell line MEB5 cells into neurons. Furthermore, chronic treatment of phenylbutenoid dimer from Indonesian ginger enhanced hippocampal neurogenesis in dementia model OBX mice.
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Report
(4 results)
Research Products
(73 results)
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[Journal Article] Syntheses of Structurally-simplified and Fluorescently-labeled Neovibsanin Derivatives and Analysis of their Neurite Outgrowth Activity in PC12 Cells.2012
Author(s)
H.Imagawa, H. Siajo, H. Yamaguchi, K. Maekwa, T. Kurisaki, H. Yamamoto, M. Nishizawa, M. Oda, M. Kaubura, M. Nagahama, J. Sakurai, M. Nakai, K. Makino, M. Ogata, H. Takahashi, Y. Fukuyama
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Journal Title
Bioorg. Med. Chem. Lett.
Volume: 22,(5)
Issue: 5
Pages: 2089-2093
DOI
Related Report
Peer Reviewed
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[Journal Article] Invasion Inhibitors of Human Fibrosarcoma HT 1080 Cells from the Rhizomes of <i>Zingiber cassumunar</i>: Structures of Phenylbutanoids, Cassumunols2011
Author(s)
Matsuda, H., Nakamura, S., Iwami, J., Li, X., Pongpiriyadacha, Y., Nakai, M., Kubo, M., Fukuyama, Y., Yoshikawa, M
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Journal Title
Chemical and Pharmaceutical Bulletin
Volume: 59
Issue: 3
Pages: 365-370
DOI
NAID
ISSN
0009-2363, 1347-5223
Related Report
Peer Reviewed
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[Presentation] インドネシア産ショウガ科食用植物BANGLEの老化促進モデルマウスに対する空間学習記憶改善作用2014
Author(s)
仲井めぐみ,飯塚美知郎,平田歩,八木祐助,常風邪興平,横田淳子,吉岡三郎,原田研一,久保美和,福山愛保,宮村充彦
Organizer
日本薬学会第134年会
Place of Presentation
熊本
Related Report
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