| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
Efficient drug delivery system (DDS) must fulfill paradoxical requirements as it should secure the cargo in the off-target environment, and also release the cargo at the target cells. Using a combination of Forster resonance energy transfer (FRET) and intravital imaging techniques, the intravital distribution and intactness of the DDS was evaluated. Intravital performance of the DDS was assessed in many aspects such as blood circulation studies, tissue distribution, intracellular stability, and release of the nucleic acid.
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