Intravital FRET Monitoring for Systematic Evaluation of Drug Delivery Systems

• Project/Area Number: 23790043
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Physical pharmacy
• Research Institution: The University of Tokyo
• Principal Investigator: MATSUMOTO Yu 東京大学, 医学部附属病院, 助教 (80548553)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: ドラッグデリバリー / 生体イメージング

Research Abstract

Efficient drug delivery system (DDS) must fulfill paradoxical requirements as it should secure the cargo in the off-target environment, and also release the cargo at the target cells. Using a combination of Forster resonance energy transfer (FRET) and intravital imaging techniques, the intravital distribution and intactness of the DDS was evaluated. Intravital performance of the DDS was assessed in many aspects such as blood circulation studies, tissue distribution, intracellular stability, and release of the nucleic acid.

Research Products

• [Journal Article] An Injectable Spheroid System with Genetic Modification for Cell Transplantation Therapy (2014)
  • Author(s): Uchida S, Itaka K, Nomoto T, Endo T, Matsumoto Y, Ishii T, Kataoka K
  • Journal Title: Biomaterials Volume: 35 Pages: 2499-506
  • Peer Reviewed
• [Journal Article] Multicompartment Micelles with Adjustable Poly(Ethylene Glycol) Shell for Efficient in Vivo Photodynamic Therapy (2014)
  • Author(s): Synatschke CV, Nomoto T, Cabral H, Fortsch M, Toh K, Matsumoto Y, Miyazaki K, Hanisch A, Schacher FH, Kishimura A, Nishiyama N, Muller AH, Kataoka K
  • Journal Title: ACS Nano Volume: 8 Pages: 1161-72
  • Peer Reviewed
• [Journal Article] Aggregation Behavior of Cationic Nanohydrogel Particles in Human Blood Serum (2014)
  • Author(s): Nuhn L, Gietzen S, Mohr K, Fischer K, Toh K, Miyata K, Matsumoto Y, Kataoka K, Schmidt M, Zentel R
  • Journal Title: Biomacromolecules
  • Peer Reviewed
• [Journal Article] Three-Layered Polyplex Micelle as a Multifunctional Nanocarrier Platform for Light-Induced Systemic Gene Transfer (2014)
  • Author(s): Nomoto T, Fukushima S, Kumagai M, Machitani K, Arnida, Matsumoto Y, Oba M, Miyata K, Osada K, Nishiyama N, Kataoka K
  • Journal Title: Nat Commun Volume: 5 Pages: 3545-3545
  • Peer Reviewed
• [Journal Article] Targeted Gene Delivery by Polyplex Micelles with Crowded PEG Palisade and cRGD Moiety for Systemic Treatment of Pancreatic (2014)
  • Author(s): Tumors, Ge Z, Chen Q, Osada K, Liu X, Tockary TA, Uchida S, Dirisala A, Ishii T, Nomoto T, Toh K, Matsumoto Y, Oba M, Kano MR, Itaka K, Kataoka K
  • Journal Title: Biomaterials Volume: 35 Pages: 316-26
  • Peer Reviewed
• [Journal Article] Multifunctional polyion complex micelle featuring enhanced stability, targetability, and endosome escapability for systemic siRNA delivery to subcutaneous model of lung cancer (2014)
  • Author(s): Hyun Jin Kim, Takehiko Ishii, Meng Zheng, Sumiyo Watanabe, Kazuko Toh, Yu Matsumoto, Nobuhiro Nishiyama, Kanjiro Miyata, Kazunori Kataoka
  • Journal Title: Drug Delivery and Translational Research Volume: 4 Issue: 1 Pages: 50-60
  • DOI: 10.1007/s13346-013-0175-6
  • Peer Reviewed / Open Access
• [Journal Article] An injectable spheroid system with genetic modification for cell transplantation therapy (2014)
  • Author(s): Uchida S, ltaka K, Nomoto T, Endo T, Matsumoto Y, Ishii T, Kataoka K
  • Journal Title: Biomaterials Volume: 35(8) Issue: 8 Pages: 2499-506
  • DOI: 10.1016/j.biomaterials.2013.12.012
  • Peer Reviewed
• [Journal Article] Multicompartment micelles with adjustable poly (ethylene glycol) shell for efficient in vivo photodynamic therapy (2014)
  • Author(s): C. V. Synatschke, N. Nishiyama, et al.
  • Journal Title: ACS Nano Volume: (in press)(印刷中)(掲載確定) Issue: 2 Pages: 1161-1172
  • DOI: 10.1021/nn4028294
  • Peer Reviewed
• [Journal Article] Aggregation Behavior of Cationic Nanohydrogel Particles in Human Blood Serum (2014)
  • Author(s): L. Nuhn, S. Gietzen, K. Mohr, K. Fischer, K. Toh, K. Miyata, Y. Matsumoto, K. Kataoka, M. Schmidt, R. Zentel
  • Journal Title: Biomacromolecules Volume: Article ASAP Issue: 4 Pages: 1526-1533
  • DOI: 10.1021/bm500199h
  • Peer Reviewed
• [Journal Article] Three-layered polyplex micelle as a multifunctional nanocarrier platform for light-induced systemic gene transfer (2014)
  • Author(s): T. Nomoto, S. Fukushima, M. Kumagai, K. Machitani, Arnida, Y. Matsumoto, M. Oba, K. Miyata, K. Osada, N. Nishiyama, K. Kataoka
  • Journal Title: Nature Communications Volume: 5 Issue: 1 Pages: 3545-3545
  • DOI: 10.1038/ncomms4545
  • Peer Reviewed / Open Access
• [Journal Article] Targeted gene delivery by polyplex micelles with crowded PEG palisade and cRGD moiety for systemic treatment of pancreatic tumors (2014)
  • Author(s): Z. Ge, Q. Chen, K. Osada, X. Liu, T. A. Tockary, S. Uchida, A. Dirisala, T. Ishii, T. Nomoto, K. Toh, Y. Matsumoto, M. Oba, M. R. Kano, K. Itaka, K. Kataoka
  • Journal Title: Biomaterials Volume: 35 Issue: 10 Pages: 3416-3426
  • DOI: 10.1016/j.biomaterials.2013.12.086
  • Peer Reviewed
• [Journal Article] 他領域からのトピックスナノバイオテクノロジーを応用した医療イノベーション (2013)
  • Author(s): 松本有,山岨達也,片岡一則
  • Journal Title: 日本耳鼻咽喉科学会会報 Volume: 113 Pages: 133-139
• [Journal Article] A Toolbox of Differently Sized and Labeled PMMA Nanoparticles for Cellular Uptake Investigations (2013)
  • Author(s): Vollrath A, Schallon A, Pietsch C, Schubert S, Nomoto T, Matsumoto Y, Kataoka K, Schubert US
  • Journal Title: Soft Matter Volume: 9 Pages: 99-108
  • Peer Reviewed
• [Journal Article] Tethered PEG Crowdedness Determining Shape and Blood Circulation Profile of Polyplex Micelle Gene Carriers (2013)
  • Author(s): Tockary TA, Osada K, Chen Q, Machitani K, Dirisala A, Uchida S, Nomoto T, Toh K, Matsumoto Y, Itaka K, Nitta K, Nagayama K, Kataoka K
  • Journal Title: Macromolecules Volume: 46 Pages: 6585-6592
  • Peer Reviewed
• [Journal Article] Cyclic RGD-Linked Polymeric Micelles for Targeted Delivery of Platinum Anticancer Drugs to Glioblastoma through the Blood-Brain Tumor Barrier (2013)
  • Author(s): Miura Y, Takenaka T, Toh K, Wu S, Nishihara H, Kano MR, Ino Y, Nomoto T, Matsumoto Y, Koyama H, Cabral H, Nishiyama N, Kataoka K
  • Journal Title: ACS Nano Volume: 7 Pages: 8583-92
  • Peer Reviewed
• [Journal Article] Lipid Envelope-Type Nanoparticle Incorporating a Multifunctional Peptide for Systemic SiRNA Delivery to the Pulmonary Endothelium (2013)
  • Author(s): Kusumoto K, Akita H, Ishitsuka T, Matsumoto Y, Nomoto T, Furukawa R, El-Sayed A, Hatakeyama H, Kajimoto K, Yamada Y, Kataoka K, Harashima H
  • Journal Title: ACS Nano Volume: 7 Pages: 73534-41
  • Peer Reviewed
• [Journal Article] Multifunctional Polyion Complex Micelle Featuring Enhanced Stability, Targetability, and Endosome Escapability for Systemic SiRNA Delivery to Subcutaneous Model of Lung Cancer (2013)
  • Author(s): Kim HJ, Ishii T, Zheng M, Watanabe S, Toh K, Matsumoto Y, Nishiyama N, Miyata K, Kataoka K, Drug Delivery and Translational
  • Journal Title: Research Volume: 4 Pages: 50-60
  • Peer Reviewed
• [Journal Article] 他領域からのトピックス ナノバイオテクノロジーを応用した医療イノベーション (2013)
  • Author(s): 松本有, 山岨達也, 片岡一則
  • Journal Title: 日本耳鼻咽喉科学会会報 Volume: 113 Pages: 133-139
• [Journal Article] A toolbox of differently sized and labeled PMMA nanoparticles for cellular uptake investigations (2013)
  • Author(s): A. Vollrath, A. Schallon, C. Pietsch, S. Schubert, T. Nomoto, Y. Matsumoto, U. S. Schubert, K. Kataoka
  • Journal Title: Soft Matter Volume: 9(1) Issue: 1 Pages: 99-108
  • DOI: 10.1039/c2sm26928g
  • Peer Reviewed
• [Journal Article] Cyclic RGD-linked polymeric micelles for targeted delivery of platinum anticancer drugs to glioblastoma through the blood-brain tumor barrier (2013)
  • Author(s): Y. Miura, N. Nishiyama, et al.
  • Journal Title: ACS Nano Volume: 7 Issue: 10 Pages: 8583-8592
  • DOI: 10.1021/nn402662d
  • Peer Reviewed
• [Journal Article] A Lipid Envelop-type Nano Particle Incorporating a Multifunctional Peptide: GALA for the Systemic siRNA Delivery to the Pulmonary Endothelium. (2013)
  • Author(s): Kusumoto K, Akita H, Ishitsuka T, Matsumoto Y, Nomoto T, Furukawa R, El-Sayed A, Hatakeyama H, Kajimoto K, Yamada Y, Kataoka K, Harashima H.
  • Journal Title: ACS Nano. Volume: 7 Issue: 9 Pages: 7534-7541
  • DOI: 10.1021/nn401317t
  • Peer Reviewed
• [Journal Article] リアルタイム生体内共焦点レーザ顕微鏡を用いたDrug Delivery Systems(DDS)の動態評価法 (2012)
  • Author(s): 野本貴大,松本有,藤加珠子, Christie RJ,宮田完二郎,大庭誠, Cabral H,村上真美,福島重人,西山伸宏,片岡一則
  • Journal Title: 薬学雑誌 Volume: 132 Pages: 1347-54
  • NAID: 130002489530
• [Journal Article] PEG-Detachable Cationic Polyaspartamide Derivatives Bearing Stearoyl Moieties for Systemic SiRNA Delivery toward Subcutaneous BxPC3 Pancreatic Tumor (2012)
  • Author(s): Kim HJ, Oba M, Pittella F, Nomoto T, Cabral H, Matsumoto Y, Miyata K, Nishiyama N, Kataoka K
  • Journal Title: J Drug Target Volume: 20 Pages: 33-42
  • Peer Reviewed
• [Journal Article] Targeted Polymeric Micelles for SiRNA Treatment of Experimental Cancer by Intravenous Injection (2012)
  • Author(s): Christie RJ, Matsumoto Y, Miyata K, Nomoto T, Fukushima S, Osada K, Halnaut J, Pittella F, Kim HJ, Nishiyama N, Kataoka K
  • Journal Title: ACS Nano Volume: 6 Pages: 5174-89
  • Peer Reviewed
• [Journal Article] Micellization of Cisplatin (NC-6004) Reduces its Ototoxicity in Guinea Pigs (2012)
  • Author(s): Baba M, Matsumoto Y, Kashio A, Cabral H, Nishiyama N, Kataoka K, Yamasoba T
  • Journal Title: J Control Release Volume: 157 Pages: 112-7
  • Peer Reviewed
• [Journal Article] Dual antrostomy optical window for visualising sinus cavity during implant restoration (2012)
  • Author(s): Y. Matsumoto, T. Okuno, Y. Hasegawa, M. Kuwauchi
  • Journal Title: BMJ Case Rep Volume: なし Issue: jun22 1 Pages: bcr0220125869-bcr0220125869
  • DOI: 10.1136/bcr.02.2012.5869
  • Peer Reviewed
• [Journal Article] Targeted polymeric micelles for siRNA treatment of experimental cancer by intravenous injection (2012)
  • Author(s): R. J. Christie, Y. Matsumoto, K. Miyata, T. Nomoto, S. Fukushima, K. Osada, J. Halnaut, F. Pittella, H. -J. Kim, N. Nishiyama, K. Kataoka
  • Journal Title: ACS Nano Volume: 6(6) Issue: 6 Pages: 5174-5189
  • DOI: 10.1021/nn300942b
  • Peer Reviewed
• [Journal Article] Micellization of cisplatin (NC-6004) reduces its ototoxicity in guinea pigs (2012)
  • Author(s): M.Baba, N.Nishiyama, et al.
  • Journal Title: J.Control.Release Volume: 157 Issue: 1 Pages: 112-117
  • DOI: 10.1016/j.jconrel.2011.07.026
  • Peer Reviewed
• [Journal Article] ムコイド型肺炎球菌を起因菌とした耳性頭蓋内合併症の2例 (2012)
  • Author(s): 桑内麻也子, 奥野妙子, 畑裕子, 松本有, 小嶋康隆
  • Journal Title: Otology Japan Volume: 22 Pages: 141-147
  • NAID: 10030646737
  • Peer Reviewed
• [Journal Article] 先天性真珠腫手術症例39例の検討 (2012)
  • Author(s): 小嶋康隆, 奥野妙子, 畑裕子, 松本有, 田中友佳子, 井之口豪
  • Journal Title: Otology Japan Volume: 22 Pages: 17-22
  • NAID: 10030285412
  • Peer Reviewed
• [Journal Article] リアルタイム生体内共焦点レーザ顕微鏡を用いた drug delivery systems(DDS)の動態評価法 (2012)
  • Author(s): 野本貴大, 松本有, 藤加珠子, R. J. Christie, 宮田完二郎, 大庭誠, H. Cabral, 村上真美, 福島重人, 西山伸宏, 片岡一則
  • Journal Title: 薬学雑誌 Volume: 132 Pages: 1347-1354
  • NAID: 130002489530
• [Journal Article] In Situ Quantitative Monitoring of Polyplexes and Polyplex Micelles in the Blood Circulation Using Intravital Real-Time Confocal Laser Scanning Microscopy (2011)
  • Author(s): Nomoto T, Matsumoto Y, Miyata K, Oba M, Fukushima S, Nishiyama N, Yamasoba T, Kataoka K
  • Journal Title: J Control Release Volume: 151 Pages: 104-9
  • Peer Reviewed
• [Journal Article] I mproving Drug Potency and Efficacy by Nanocarrier-Mediated Subcellular Targeting (2011)
  • Author(s): Murakami M, Cabral H, Matsumoto Y, Wu S, Kano MR, Yamori T, Nishiyama N, Kataoka K
  • Journal Title: Sci Transl Med Volume: 3
  • Peer Reviewed
• [Journal Article] Effect of Polymer Structure on Micelles Formed between Sirna and Cationic Block Copolymer Comprising Thiols and Amidines (2011)
  • Author(s): Christie RJ, Miyata K, Matsumoto Y, Nomoto T, Menasco D, Lai TC, Pennisi M, Osada K, Fukushima S, Nishiyama N, Yamasaki Y, Kataoka K
  • Journal Title: Biomacromolecules Volume: 12 Pages: 3174-85
  • Peer Reviewed
• [Journal Article] Accumulation of Sub-100 Nm Polymeric Micelles in Poorly Permeable Tumours Depends on Size (2011)
  • Author(s): Cabral H, Matsumoto Y, Mizuno K, Chen Q, Murakami M, Kimura M, Terada Y, Kano MR, Miyazono K, Uesaka M, Nishiyama N, Kataoka K
  • Journal Title: Nat Nanotechnol Volume: 6 Pages: 815-23
  • Peer Reviewed
• [Journal Article] PEG-detachable cationic polyaspartamide detivatives bearing stearoyl moieties for systemic siRNA delivery toward subcutaneous BxPC3 pancreatic tumor (2011)
  • Author(s): H.-J.Kim, N.Nishiyama, et al
  • Journal Title: J.Drug Target. Volume: 20 Issue: 1 Pages: 33-42
  • DOI: 10.3109/1061186x.2011.632010
  • Peer Reviewed
• [Journal Article] 生体内リアルタイム共焦点顕微鏡 (2011)
  • Author(s): 松本有, 野本貴大, 藤加珠子, 片岡一則
  • Journal Title: Drug Delivery System Volume: 26 Pages: 535-539
• [Journal Article] Effect of polymer structure on micelles formed between siRNA and cationic block copolymer Comprising thiols and amidines (2011)
  • Author(s): R. J. Christie, K. Miyata, Y. Matsumoto, T. Nomoto, D. Menasco, T.-C. Lai, M. Pennisi, K. Osada, S. Fukushima, N. Nishiyama, Y. Yamasaki, K. Kataoka
  • Journal Title: Biomacromolecules Volume: 12(9) Issue: 9 Pages: 3174-3185
  • DOI: 10.1021/bm2006714
  • Peer Reviewed
• [Journal Article] Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size (2011)
  • Author(s): H. Cabral, Y. Matsumoto, K. Mizuno, Q. Chen, M. Murakami, M. Kimura, Y. Terada, M. R. Kano, K. Miyazono, M. Uesaka, N. Nishiyama, K. Kataoka
  • Journal Title: Nature Nanotech Volume: 6(12) Issue: 12 Pages: 815-823
  • DOI: 10.1038/nnano.2011.166
  • Peer Reviewed
• [Journal Article] 下咽頭神経鞘腫の1例 (2011)
  • Author(s): 田中友佳子, 栗田宣彦, 松本有, 原田品子, 佐多由紀, 畑裕子, 小嶋康隆, 奥野妙子
  • Journal Title: 耳鼻咽喉科・頭頚部外科 Volume: 83 Pages: 595-599
  • Peer Reviewed
• [Presentation] Intravital Confocal Microscopy Assay for the Evaluation of Antioxidant Capacity (2014)
  • Author(s): Matsumoto Y
  • Organizer: 37th Annual MidWinter Research Meeting of the Association for Research in Otolaryngology
  • Place of Presentation: Manchester Grand Hyatt Hotel, San Diego, CA, USA
  • Year and Date: 2014-02-24
• [Presentation] Intravital Imaging of Drug Delivery Systems and Auditory Hair Cells (2013)
  • Author(s): Matsumoto Y
  • Organizer: 12th Taiwan-Japan Conference on Otolaryngology Head and Neck Surgery
  • Place of Presentation: National Taiwan University Hospital, Taipei City, Taiwan
  • Year and Date: 2013-12-06
• [Presentation] Intravital Calcium Imaging of Cochlear Hair Cells Upon Sound Stimulation (2013)
  • Author(s): Matsumoto Y
  • Organizer: 50th Inner Ear Biology Workshop
  • Place of Presentation: Universidad de Alcalá, Alcalá de Henares, Madrid, Spain
  • Year and Date: 2013-09-11
• [Presentation] Intravital Calcium Imaging of Cochlear Hair Cells (2013)
  • Author(s): Matsumoto Y
  • Organizer: 36th Annual MidWinter Research Meeting of the Association for Research in Otolaryngology
  • Place of Presentation: Baltimore Marriott Waterfront Hotel, Baltimore, MD, USA
  • Year and Date: 2013-02-18
• [Presentation] Intravital Confocal Microscopy for Dds Evaluation and Development (2013)
  • Author(s): Matsumoto Y, Sheraton
  • Organizer: 16th International Symposium on Recent Advances in Drug Delivery Systems
  • Place of Presentation: Salt Lake City Hotel, Salt Lake City, UT, USA
  • Year and Date: 2013-02-06
• [Presentation] DDS Evaluation Using Intravital Real-Time Laser Scanning Confocal Microscopy (2013)
  • Author(s): Matsumoto Y
  • Organizer: 40th Annual Meeting & Exposition of the Controlled Release Society
  • Place of Presentation: Hawaii Convention Center, Honolulu, HI, USA
• [Presentation] Intravital Microscopy for DDS Evaluation and Development (2013)
  • Author(s): Matsumoto Y
  • Organizer: The 12th US-Japan Symposium on Drug Delivery Systems
  • Place of Presentation: The Westin Maui Resort and Spa, Lahaina, Maui, HI, USA
• [Presentation] Enhanced blood circulation of siRNA complexed with PEG-block-poly(L-lysine) for cancer treatment (2013)
  • Author(s): S. Watanabe, H. Chaya, T. Nomoto, S. Fukushima, K. Toh, H. Takemoto, X. Liu, Y. Matsumoto, S. Uchida, M. Nangaku, K. Osada, N. Nishiyama, K. Miyata, K. Kataoka
  • Organizer: 40th Annual Meeting & Exposition of the Controlled Release Society
  • Place of Presentation: Hawaii Convention Center, Honolulu, HI, USA
• [Presentation] Intravital Monitoring of Intact siRNA Using Fluorescence Resonance Energy Transfer (2013)
  • Author(s): K. Toh, T. Nomoto, Y. Matsumoto, S. Watanabe, S. Fukushima, H. Chaya, R. J. Christie, K. Miyata, N. Nishiyama, K. Kataoka
  • Organizer: 40th Annual Meeting & Exposition of the Controlled Release Society
  • Place of Presentation: Hawaii Convention Center, Honolulu, HI, USA
• [Presentation] Tethering PEG density on polyplex micelles and stealthiness in blood circulation (2013)
  • Author(s): K. Osada, T. Tockary, Q. Chen, A. Dirisala, K. Machitani, T. Nomoto, Y. Matsumoto, K. Kataoka
  • Organizer: 40th Annual Meeting & Exposition of the Controlled Release Society
  • Place of Presentation: Hawaii Convention Center, Honolulu, HI, USA
• [Presentation] Enhanced Antitumor Activity of Proteasome Inhibitor MG132-loaded Polymeric Micelle Drug Carriers (2013)
  • Author(s): Y. Matsumoto, Y. Miyamoto, K. Nagasaka, Y. Matsumoto, H. Cabral, H. Nishida, R. J. Christie, K. Kawana, T. Fujii, N. Nishiyama, K. Kataoka
  • Organizer: 40th Annual Meeting & Exposition of the Controlled Release Society
  • Place of Presentation: Hawaii Convention Center, Honolulu, HI, USA
• [Presentation] Development of enzyme-loaded PICsomes for enzyme/prodrug therapy (2013)
  • Author(s): Y. Anraku, A. Kishimura, M. Kamiya, S. Tanaka, T. Nomoto, K. Toh, Y. Matsumoto, M. R. Kano, Y. Urano, N. Nishiyama, K. Kataoka
  • Organizer: 40th Annual Meeting & Exposition of the Controlled Release Society
  • Place of Presentation: Hawaii Convention Center, Honolulu, HI, USA
• [Presentation] PIC型ベシクルの特徴を活かした酵素プロドラッグ療法用キャリアの構築 (2013)
  • Author(s): 安楽泰孝, 岸村顕広, 神谷真子, 田中さやか, 野本貴大, 藤加珠子, 松本有, 狩野光伸, 浦野泰照, 西山伸宏, 片岡一則
  • Organizer: 第62回高分子学会年次大会
  • Place of Presentation: 京都国際会館、京都府京都市
• [Presentation] siRNA 1 分子封入ポリイオンコンプレックスの構築と siRNA デリバリーへの展開 (2013)
  • Author(s): 宮田完二郎, 茶谷洋行, 渡邉秀美代, 林光太朗, 野本貴大, 藤加珠子, 松本有, 武元宏泰, 西山伸宏, 長田健介, 片岡一則
  • Organizer: 第35回日本バイオマテリアル学会
  • Place of Presentation: タワーホール船堀、東京都江戸川区
• [Presentation] 生体内顕微鏡下におけるFörster Resonance Energy Transferを利用した血中siRNA安定性の定量的評価 (2013)
  • Author(s): 藤加珠子, 野本貴大, 松本有, 渡邉秀美代, 福島重人, 茶谷洋行, R. J. Christie, 宮田完二郎, 西山伸宏, 片岡一則
  • Organizer: 第35回日本バイオマテリアル学会
  • Place of Presentation: タワーホール船堀、東京都江戸川区
• [Presentation] 生体内リアルタイム共焦点顕微鏡の手技の実際 (2012)
  • Author(s): 松本有
  • Organizer: 第28回日本DDS学会学術集会
  • Place of Presentation: 札幌コンベンションセンター、北海道札幌市
  • Year and Date: 2012-07-05
• [Presentation] 生体内リアルタイム共焦点顕微鏡によるDDS挙動解析 (2012)
  • Author(s): 松本有
  • Organizer: 第28回日本DDS学会学術集会
  • Place of Presentation: 札幌コンベンションセンター、北海道札幌市
  • Year and Date: 2012-07-05
• [Presentation] 生体内リアルタイム共焦点顕微鏡の手技の実際（招待講演） (2012)
  • Author(s): 松本有
  • Organizer: 第28回日本DDS学会学術集会
  • Place of Presentation: 札幌コンベンションセンター、北海道札幌市
  • Invited
• [Presentation] 生体内リアルタイム共焦点顕微鏡によるDDS挙動解析（招待講演） (2012)
  • Author(s): 松本有
  • Organizer: 第28回日本DDS学会学術集会
  • Place of Presentation: 札幌コンベンションセンター、北海道札幌市
  • Invited
• [Presentation] Size-mediated Accumulation of Sub-100 nm Polymeric Micelles in Poorly Permeable Tumors (2012)
  • Author(s): H. Cabral, 松本有, 狩野光伸, 西山伸宏, 片岡一則
  • Organizer: 第28回日本DDS学会学術集会
  • Place of Presentation: 札幌コンベンションセンター、北海道札幌市
• [Presentation] 生体内リアルタイム共焦点顕微鏡を用いたポリイオンコンプレックスの定量的血中動態評価 (2012)
  • Author(s): 野本貴大, 松本有, 宮田完二郎, 大庭誠, 福島重人, 西山伸宏, 片岡一則
  • Organizer: 第28回日本DDS学会学術集会
  • Place of Presentation: 札幌コンベンションセンター、北海道札幌市
• [Presentation] 肺血管内皮細胞標的型siRNAキャリアの標的メカニズムとその抗腫瘍効果 (2012)
  • Author(s): 楠本憲司, 秋田英万, 松本有, 野本貴大, 片岡一則, 原島秀吉
  • Organizer: 第28回日本DDS学会学術集会
  • Place of Presentation: 札幌コンベンションセンター、北海道札幌市
• [Presentation] インプラント治療に伴う上顎洞炎・自然口および対孔Optical Windowを利用した長期経過観察 (2012)
  • Author(s): 松本有, 小嶋康隆, 田中友佳子, 桑内麻也子, 畑裕子, 栗田宣彦, 山岨達也, 奥野妙子
  • Organizer: 第113回日本耳鼻咽喉科学会・学術講演会
  • Place of Presentation: 朱鷺メッセ、新潟県新潟市
• [Presentation] 耳の「低侵襲内視鏡」手術: transmeatal approach (2012)
  • Author(s): 奥野妙子, 畑裕子, 栗田宣彦, 松本有, 小嶋康隆, 桑内麻也子
  • Organizer: 第113回日本耳鼻咽喉科学会・学術講演会
  • Place of Presentation: 朱鷺メッセ、新潟県新潟市
• [Presentation] 当科における耳硬化症の聴力像の検討 (2012)
  • Author(s): 桑内麻也子, 奥野妙子, 小嶋康隆, 松本有, 畑裕子, 栗田宣彦
  • Organizer: 第113回日本耳鼻咽喉科学会・学術講演会
  • Place of Presentation: 朱鷺メッセ、新潟県新潟市
• [Presentation] 当科における耳硬化症手術症例の画像所見と治療成績 (2012)
  • Author(s): 小嶋康隆, 奥野妙子, 畑裕子, 阿部彰子, 松本有, 栗田宣彦, 桑内麻也子
  • Organizer: 第113回日本耳鼻咽喉科学会・学術講演会
  • Place of Presentation: 朱鷺メッセ、新潟県新潟市
• [Presentation] Enhanced Blood Circulation Properties of siRNA Nanocarriers by Fine-tuning of PEG-block-Poly(L-lysine) (2012)
  • Author(s): S. Watanabe, H. Chaya, K. Miyata, T. Nomoto, S. Fukushima, H. Takemoto, K. Toh, L. Xueying, Y. Matsumoto, K. Osada, N. Nishiyama, K. Kataoka
  • Organizer: 6th Annual Symposium on Nanobiotechnology Kyoto Cell-Material Integration
  • Place of Presentation: Shirankaikan, Kyoto University, Kyoto, Japan
• [Presentation] A Light-responsive Nanodevice Based on Photochemical Internalization (2012)
  • Author(s): T. Nomoto, S. Fukushima, M. Kumagai, K. Machitani, K. Miyata, M. Oba, Y. Matsumoto, K. Osada, N. Nishiyama, K. Kataoka
  • Organizer: 6th Annual Symposium on Nanobiotechnology Kyoto Cell-Material Integration
  • Place of Presentation: Shirankaikan, Kyoto University, Kyoto, Japan
• [Presentation] Targeted Polymeric Micelles for siRNA Cancer Therapy Administered by Intravenous Injection (2012)
  • Author(s): R. J. Christie, Y. Matsumoto, S. Fukushima, T. Nomoto, K. Miyata, K. Osada, F. Pittella, H. J. Kim, H. Nishida, N. Nishiyama, K. Kataoka
  • Organizer: NanoBio Seattle 2012 (The Fourth International NanoBio Conference)
  • Place of Presentation: Bell Harbor International Conference Center, Seattle, WA, USA
• [Presentation] Imaging DDS Using Intravital Real-Time Confocal Microscopy (2011)
  • Author(s): Matsumoto Y
  • Organizer: The 11th US-Japan Symposium on Drug Delivery Systems
  • Place of Presentation: The Westin Maui Resort and Spa, Lahaina, Maui, HI, USA
  • Year and Date: 2011-12-18
• [Presentation] 生体内リアルタイム共焦点顕微鏡と蝸牛イメージングへの展開 (2011)
  • Author(s): 松本有
  • Organizer: 第21回日本耳科学会総会
  • Place of Presentation: 学術講演会,沖縄コンベンションセンター、沖縄県宜野湾市
  • Year and Date: 2011-11-24
• [Presentation] 生体内リアルタイム共焦点顕微鏡を用いたDDS機能評価 (2011)
  • Author(s): 松本有
  • Organizer: 第27回日本DDS学会
  • Place of Presentation: 東京大学、東京都文京区
  • Year and Date: 2011-06-09
• [Presentation] Intravital Confocal Micro - Videography (2011)
  • Author(s): Matsumoto Y
  • Organizer: International Conference on Biomaterials Science (ICBS) 2011
  • Place of Presentation: Tsukuba International Congress Center, Tsukuba, Ibaraki, Japan
  • Year and Date: 2011-03-16
• [Presentation] Intravital Real-Time Confocal Laser Scanning Microscopy for In Situ Evaluation of Nanocarriers (2011)
  • Author(s): Yu Matsumoto, Takahiro Nomoto, Kazuko Toh, Kanjiro Miyata, Horacio Cabral, R. James Christie, Yoko Matsumoto, Nobuhiro Nishiyama, Tatsuya Yamasoba, Kazunori Kataoka
  • Organizer: The 11th US-Japan Symposium on Drug Delivery Systems
  • Place of Presentation: The Westin Maui Resort and Spa, Lahaina, Maui, Hawaii, USA
• [Presentation] 生体内リアルタイム共焦点顕微鏡と蝸牛イメージングへの展開 (2011)
  • Author(s): 松本有, 狩野章太郎, 吉川弥生, 奥野妙子, 片岡一則, 山岨達也
  • Organizer: 第21回日本耳科学会総会・学術講演会
  • Place of Presentation: 沖縄コンベンションセンター, 沖縄県宜野湾市
• [Presentation] 生体内リアルタイム共焦点顕微鏡を用いたDDS機能評価 (2011)
  • Author(s): 松本有, 野本貴大, カブラルオラシオ, 村上真美, 西山伸宏, 山崎裕一, 山岨達也, 片岡一則
  • Organizer: 第27回日本DDS学会
  • Place of Presentation: 東京大学本郷キャンパス, 東京都文京区
• [Presentation] Clinical Course and Features of Fatal Intersititial Pneumonitis Induced by PEGylated Liposomal Doxorubicin (PLD) and Analysis of PLD-Induced Lung Injury Using Real-Time Intravital Microscope (2011)
  • Author(s): Yoko Matsumoto, Takahide Arimoto, Katsutoshi Oda, Kei Kawana, Tetsu Yano, Yuji Taketani, Yu Matsumoto, Takahiro Nomoto, Kazuko Toh, Kazunori Kataoka
  • Organizer: The 11th US-Japan Symposium on Drug Delivery Systems
  • Place of Presentation: The Westin Maui Resort and Spa, Lahaina, Maui, Hawaii, USA
• [Presentation] Observation and Analysis of Radiation-Induced Vascular Permeability to Improve the Delivery of Polymeric Micelles by IVRTCLSM (2011)
  • Author(s): Hiroshi Fujisawa, Horacio Cabral, Takahiro Nomoto, Mitsuru Uesaka, Kazue Mizuno, Kazuko Toh, Yu Matsumoto, Nobuhiro Nishiyama, Kazunori Kataoka
  • Organizer: The 11th US-Japan Symposium on Drug Delivery Systems
  • Place of Presentation: The Westin Maui Resort and Spa, Lahaina, Maui, Hawaii, USA
• [Presentation] Quantitative evaluation of dynamic states of polyplexes and polyplex micelles in blood stream using intravital real-time confocal laser scanning microscopy (2011)
  • Author(s): Takahiro Nomoto, Yu Matsumoto, Kanjiro Miyata, Makoto Oba, Shigeto Fukushima, Nobuhiro Nishiyama, Kazunori Kataoka
  • Organizer: The 11th US-Japan Symposium on Drug Delivery Systems
  • Place of Presentation: The Westin Maui Resort and Spa, Lahaina, Maui, Hawaii, USA
• [Presentation] ダイビングが誘因となった急性聴覚前庭障害の2症例 (2011)
  • Author(s): 畑裕子, 小嶋康隆, 松本有, 田中友佳子, 桑内麻也子, 馬場美雪, 奥野妙子, 池園哲朗
  • Organizer: 第21回日本耳科学会総会・学術講演会
  • Place of Presentation: 沖縄コンベンションセンター, 沖縄県宜野湾市
• [Presentation] 中耳真珠腫進展度分類2010改訂案に基づいた真珠腫性中耳炎の手術成績の検討 (2011)
  • Author(s): 小嶋康隆, 奥野妙子, 畑裕子, 松本有, 桑内麻也子
  • Organizer: 第21回日本耳科学会総会・学術講演会
  • Place of Presentation: 沖縄コンベンションセンター, 沖縄県宜野湾市
• [Presentation] 肺炎球菌を起炎菌とした耳性頭蓋合併症の2例 (2011)
  • Author(s): 桑内麻也子, 奥野妙子, 畑裕子, 松本有, 小嶋康隆
  • Organizer: 第21回日本耳科学会総会・学術講演会
  • Place of Presentation: 沖縄コンベンションセンター, 沖縄県宜野湾市
• [Presentation] シスプラチン内包高分子ミセルの内耳毒性軽減効果 (2011)
  • Author(s): 馬場美雪, 松本有, 樫尾明憲, 片岡一則, 山岨達也
  • Organizer: 第21回日本耳科学会総会・学術講演会
  • Place of Presentation: 沖縄コンベンションセンター, 沖縄県宜野湾市
• [Presentation] 若手耳科医師の教育プログラム (2011)
  • Author(s): 奥野妙子, 畑裕子, 松本有, 小嶋康隆
  • Organizer: 第21回日本耳科学会総会・学術講演会
  • Place of Presentation: 沖縄コンベンションセンター, 沖縄県宜野湾市
• [Presentation] In Situ Monitoring of Drug Delivery Systems Using Intravital Real-time Confocal Laser Scanning Microscopy (2011)
  • Author(s): Takahiro Nomoto, Yu Matsumoto, Kanjiro Miyata, Makoto Oba, Shigeto Fukushima, Horacio Cabral, Mami Murakami, Nobuhiro Nishiyama, Kazunori Kataoka
  • Organizer: Seoul Nanohealth 2011 Symposium
  • Place of Presentation: Yonsei University, Seoul, Korea
• [Presentation] A Photo-activated Nanodevice Having Three Functional Compartments for Efficient Gene Delivery (2011)
  • Author(s): Takahiro Nomoto, Shigeto Fukushima, Michiaki Kumagai, Kanjiro Miyata, Yu Matsumoto, Makoto Oba, Woo-dong Jang, Nobuhiro Nishiyama, Kazunori Kataoka
  • Organizer: Seoul Nanohealth 2011 Symposium
  • Place of Presentation: Yonsei University, Seoul, Korea
• [Presentation] PEG-detachable polyaspartamide derivative block copolymer bearing stearoyl moieities for in vivo siRNA delivery (2011)
  • Author(s): Kim Hyun Jin, M. Oba, F. Pittella, T. Nomoto, H. Cabral, Y. Matsumoto, K. Miyata, N. Nishiyama, K. Kataoka
  • Organizer: 第60回高分子討論会
  • Place of Presentation: 岡山大学津島キャンパス、岡山県岡山市
• [Presentation] 21.Subcellular delivery of DACHPt by polymeric micelles overcomes oxaliplatin resistance in Human Colon Carcinoma (2011)
  • Author(s): Mami Murakami, Horacio Cabral, Yu Matsumoto, Shourong Wu, Takao Yamori, Nobuhiro Nishiyama, Kazunori Kataoka
  • Organizer: 38th Annual Meeting & Exposition of the Controlled Release Society
  • Place of Presentation: Gaylord National Hotel and Convention Center, National Harbor, Maryland, USA
• [Presentation] 22.Quantitative Monitoring of Polyplexes and Polyplex Micelles in Bloodstream Using Intravital Real-time Confocal Laser Scanning Microscopy (2011)
  • Author(s): Takahiro Nomoto, Yu Matsumoto, Kanjiro Miyata, Makoto Oba, Shigeto Fukushima, Nobuhiro Nishiyama, Kazunori Kataoka
  • Organizer: 38th Annual Meeting & Exposition of the Controlled Release Society
  • Place of Presentation: Gaylord National Hotel and Convention Center, National Harbor, Maryland, USA
• [Presentation] Characterization of PEG-detachable polyaspartamide derivative block catiomers bearing stearoyl moieties and its VEGF siRNA delivery toward Bxpc3 xenograft tumor (2011)
  • Author(s): Kim Hyun Jin, Makoto Oba, Frederico Pittella, Horacio Cabral, Takahiro Nomoto, Yu Matsumoto, Kanjiro Miyata, Nobuhiro Nishiyama, Kazunori Kataoka
  • Organizer: 38th Annual Meeting & Exposition of the Controlled Release Society
  • Place of Presentation: Gaylord National Hotel and Convention Center, National Harbor, Maryland, USA
• [Presentation] シスプラチン内包高分子ミセルによる内耳障害軽減効果 (2011)
  • Author(s): 馬場美雪, 松本有, カブラルオラシオ, 西山伸宏, 片岡一則, 山岨達也
  • Organizer: 第27回日本DDS学会
  • Place of Presentation: 東京大学本郷キャンパス, 東京都文京区
• [Presentation] PEG-detachable polyaspartamide derivative block copolymer bearing stearoyl moieities for VEGF siRNA delivery toward pancreatic tumor (2011)
  • Author(s): Kim Hyun Jin, M. Oba, F. Pittella, T. Nomoto, H. Cabral, Y. Matsumoto, K. Miyata, N. Nishiyama, K. Kataoka
  • Organizer: 第27回日本DDS学会
  • Place of Presentation: 東京大学本郷キャンパス, 東京都文京区
• [Presentation] シリカ被覆型核酸デリバリーキャリアの開発 (2011)
  • Author(s): 宮田完二郎, Noha Gouda, 須磨知也, 松本有, 大庭誠, 西山伸宏, 片岡一則
  • Organizer: 第27回日本DDS学会
  • Place of Presentation: 東京大学本郷キャンパス, 東京都文京区
• [Presentation] 光選択的遺伝子導入を可能とする全身投与型三層構造高分子ミセル
  • Author(s): 野本貴大, 福島重人, 熊谷康顕, 町谷香織, 松本有, 大庭誠, 宮田完二郎, 長田健介, 西山伸宏, 片岡一則
  • Organizer: 第62回高分子討論会
  • Place of Presentation: 金沢大学、石川県金沢市
• [Presentation] 耳かきによる外傷性耳小骨離断の陳旧例2症例
  • Author(s): 畑裕子, 堤内亮博, 小嶋康隆, 藤田岳, 山本沙織, 松本有, 宇野茉莉子, 桑内麻也子, 一瀬和美, 奥野妙子,
  • Organizer: 第23回日本耳科学会総会・学術講演会
  • Place of Presentation: シーガイアコンベンションセンター、宮崎県宮崎市
• [Presentation] 顕微鏡と内視鏡の相補的アプローチ
  • Author(s): 松本有, 藤田岳, 宇野茉莉子, 畑裕子, 奥野妙子
  • Organizer: 第114回日本耳鼻咽喉科学会・学術講演会
  • Place of Presentation: ロイトン札幌、北海道札幌市
• [Presentation] 蝸牛有毛細胞のカルシウムイメージング
  • Author(s): 松本有, 狩野章太郎, 山岨達也
  • Organizer: 第23回日本耳科学会総会・学術講演会
  • Place of Presentation: シーガイアコンベンションセンター、宮崎県宮崎市
• [Presentation] PIC型ベシクルの特徴を活かした酵素プロドラッグ療法用キャリアの構築
  • Author(s): 安楽泰孝, 岸村顕広, 神谷真子, 田中さやか, 野本貴大, 藤加珠子, 松本有, 狩野光伸, 浦野泰照, 西山伸宏, 片岡一則
  • Organizer: 遺伝子・デリバリー研究会 第13回夏期セミナー
  • Place of Presentation: Hawaii Prince Hotel Waikiki, Honolulu, HI, USA
• [Presentation] 汎用性の高い酵素プロドラッグ療法用キャリアを指向した血中滞留型中空ナノ粒子（PICsome）の構築
  • Author(s): 安楽泰孝, 岸村顕広, 神谷真子, 田中さやか, 野本貴大, 藤加珠子, 松本有, 狩野光伸, 浦野泰照, 西山伸宏, 片岡一則
  • Organizer: 第29回日本DDS学会学術集会
  • Place of Presentation: 京都テルサ、京都府京都市
• [Presentation] 内視鏡は先天性真珠腫の手術に有効か?
  • Author(s): 奥野妙子, 松本有, 藤田岳, 堤内亮博, 宇野茉莉子, 畑裕子, 栗田宣彦
  • Organizer: 第114回日本耳鼻咽喉科学会・学術講演会
  • Place of Presentation: ロイトン札幌、北海道札幌市
• [Presentation] 耳つぼ金粒の耳管内迷入
  • Author(s): 大山博生, 五十嵐一紀, 松本有, 樫尾明憲, 柿木章伸, 山岨達也
  • Organizer: 第23回日本耳科学会総会・学術講演会
  • Place of Presentation: シーガイアコンベンションセンター、宮崎県宮崎市
• [Presentation] 耳小骨連鎖を温存した先天性・後天性真珠腫手術症例の検討
  • Author(s): 堤内亮博, 奥野妙子, 松本有, 藤田岳, 宇野茉莉子, 山本沙織, 畑裕子
  • Organizer: 第23回日本耳科学会総会・学術講演会
  • Place of Presentation: シーガイアコンベンションセンター、宮崎県宮崎市
• [Presentation] 3 次元スフェロイド細胞培養とナノミセルによる遺伝子導入を融合した新規細胞移植システム
  • Author(s): 内田智士, 位高啓史, 遠藤泰輔, 野本貴大, 松本有, 片岡一則
  • Organizer: 第29回日本DDS学会学術集会
  • Place of Presentation: 京都テルサ、京都府京都市
• [Presentation] Polymeric Micellar Nanocarriers for Systemic Light-Induced Gene Delivery
  • Author(s): T. Nomoto, S. Fukushima, M. Kumagai, K. Machitani, K. Miyata, M. Oba, Y. Matsumoto, K. Osada, N. Nishiyama, K. Kataoka
  • Organizer: 第13回東京大学生命科学シンポジウム
  • Place of Presentation: 伊藤国際学術研究センター、東京都文京区
• [Presentation] Intravital Calcium Imaging of Cochlear Hair Cells Upon Sound Stimulation
  • Author(s): Y. Matsumoto, S. Karino, S. Namiki, K. Kataoka, T. Yamasoba
  • Organizer: 50th Inner Ear Biology Workshop
  • Place of Presentation: Universidad de Alcalá, Alcalá de Henares, Madrid, Spain
• [Presentation] Systemically injected polymeric micelles can inhibit the growth of lymph node metastasis
  • Author(s): H. Cabral, J. Makino, Y. Matsumoto, Y. Miura, M. R. Kano, N. Nishiyama, K. Kataoka
  • Organizer: frontiers 2013 symposium
  • Place of Presentation: EPFL, Lausanne, Switzerland
• [Presentation] Development of Nano‐sized Polyion Complex Vesicles (Nano‐PICsomes) as a Versatile Delivery Carrier for Biomedical Application
  • Author(s): Y. Anraku, A. Kishimura, D. Kokuryo, S. I. Tanaka, M. Kamiya, K. Toh, T. Nomoto, Y. Matsumoto, I. Aoki, M. R. Kano, Y. Urano, K. Kataoka
  • Organizer: frontiers 2013 symposium
  • Place of Presentation: EPFL, Lausanne, Switzerland
• [Presentation] Intravital Imaging of Drug Delivery Systems and Auditory Hair Cells
  • Author(s): Y. Matsumoto, K. Kataoka, T. Yamasoba
  • Organizer: 12th Taiwan-Japan Conference on Otolaryngology Head and Neck Surgery
  • Place of Presentation: International Convention Center, National Taiwan University Hospital, Taipei City, Taiwan
  • Invited
• [Presentation] Intravital Confocal Microscopy Assay for the Evaluation of Antioxidant Capacity
  • Author(s): Y. Matsumoto, K. Toh, K. Kataoka, T. Yamasoba
  • Organizer: 37th Annual MidWinter Research Meeting of the Association for Research in Otolaryngology
  • Place of Presentation: Manchester Grand Hyatt Hotel, San Diego, CA, USA
• [Presentation] Optimal-sized, long-circulating single siRNA nanocarrier for intractable cancer therapy
  • Author(s): H. Chaya, S. Watanabe, K. Hayashi, H. Takemoto, S. Fukushima, T. Nomoto, K. Toh, Y. Matsumoto, K. Osada, N. Nishiyama, K. Miyata, K. Kataoka
  • Organizer: 第13回東京大学生命科学シンポジウム
  • Place of Presentation: 伊藤国際学術研究センター、東京都文京区
• [Presentation] ナノミセルを用いて遺伝子導入された3次元スフェロイド細胞の移植とその疾患治療への展開
  • Author(s): 内田智士, 位高啓史, 遠藤泰輔, 柳原歌代子, 野本貴大, 石井武彦, 松本有, 片岡一則
  • Organizer: 遺伝子・デリバリー研究会 第13回夏期セミナー
  • Place of Presentation: Hawaii Prince Hotel Waikiki, Honolulu, HI, USA
• [Presentation] 細胞接着分子カドヘリン11は中耳の正常な発達に必須である
  • Author(s): 吉川弥生, 木下淳, 松本有, 山岨達也
  • Organizer: 第23回日本耳科学会総会・学術講演会
  • Place of Presentation: シーガイアコンベンションセンター、宮崎県宮崎市
• [Book] Intravital Real-Time Confocal Laser Scanning Microscopy for the in Situ Evaluation of Nanocarriers (2013)
  • Author(s): Matsumoto Y, Nomoto T, Toh K, Cabral H, Murakami M, Christie RJ, Kim HJ, Ogura T, Miyata K, Nishiyama N, Yamasoba T, Kataoka K, Cancer Targeted Drug Delivery, Bae, Y. H., Mrsny, R. J., and Park, K.s. Bae, Y. H., Mrsny, R. J., and Park, K
  • Publisher: Springer New York
• [Book] Cancer Targeted Drug Delivery (2013)
  • Author(s): Y. Matsumoto, T. Nomoto, K. Toh, H. Cabral, M. Murakami, R. J. Christie, H. J. Kim, T. Ogura, K. Miyata, N. Nishiyama, T. Yamasoba, K. Kataoka
  • Total Pages: 720
  • Publisher: Springer New York
• [Remarks]
  • URL: http://www.bmw.t.u-tokyo.ac.jp/
• [Remarks] Welcome to KKlab homepage
  • URL: http://www.bmw.t.u-tokyo.ac.jp/index.html
• [Remarks] 片岡一則-FIRST EXPO2014
  • URL: http://first-pg.jp/about-us/kataoka-kazunori.html
• [Remarks]
  • URL: http://www.bmw.t.u-tokyo.ac.jp/index.html
• [Patent(Industrial Property Rights)] 薬剤送達用のキャリア、コンジュゲートおよびこれらを含んでなる組成物並びに投与方法 (2013)
  • Inventor(s): 片岡一則,安楽泰孝,西山伸宏,宮田 完二郎,石井武彦,松本有,福里優,溝口明祐,横田隆徳,桑原宏哉,仁科一隆,水澤英洋
  • Industrial Property Rights Holder: 東京大学工学系研究科,東京大学工学系研究科,東京大学医学系研究科,東京大学医学系研究科,東京大学工学系研究科,東京大学医学部附属病院,東京大学工学系研究科,東京大学医学系研究科,国立大学法人東京医科歯科大学,国立大学法人東京医科歯科大学,国立大学法人東京医科歯科大学,国立大学法人東京医科歯科大学
  • Industrial Property Number: 2013-242347
  • Filing Date: 2013-11-22
• [Patent(Industrial Property Rights)] 粒子組成物および該粒子組成物を用いた医薬組成物 (2012)
  • Inventor(s): 片岡一則,ロナルドジェイムズクリスティ,西山伸宏,宮田完二郎,福島重人,松本有,野本貴大,加藤泰己
  • Industrial Property Rights Holder: 東京大学工学系研究科,東京大学工学系研究科,東京大学医学系研究科,東京大学医学系研究科,東京大学工学系研究科,東京大学医学系研究科,東京大学工学系研究科,ナノキャリア株式会社
  • Filing Date: 2012-01-16
  • Overseas
• [Patent(Industrial Property Rights)] 粒子組成物および該粒子組成物を用いた医薬組成物 (2012)
  • Inventor(s): 片岡一則,ロナルドジェイムズクリスティ,西山伸宏,宮田完二郎,福島重人,松本有,野本貴大,加藤泰己
  • Industrial Property Rights Holder: 東京大学工学系研究科,東京大学工学系研究科,東京大学医学系研究科,東京大学医学系研究科,東京大学工学系研究科,東京大学医学系研究科,東京大学工学系研究科,ナノキャリア株式会社
  • Industrial Property Number: 2011-006318
  • Filing Date: 2012-01-14
• [Patent(Industrial Property Rights)] 粒子組成物および該粒子組成物を用いた医薬組成物 (2012)
  • Inventor(s): 片岡一則,ロナルドジェイムズクリスティ,西山伸宏,宮田完二郎,福島重人,松本有,野本貴大,加藤泰己
  • Industrial Property Rights Holder: 東京大学工学系研究科,東京大学工学系研究科,東京大学医学系研究科,東京大学医学系研究科,東京大学工学系研究科,東京大学医学系研究科,東京大学工学系研究科,ナノキャリア株式会社
  • Industrial Property Number: 2012-552778
  • Filing Date: 2012-01-16
• [Patent(Industrial Property Rights)] 粒子組成物および該粒子組成物を用いた医薬組成物 (2012)
  • Inventor(s): 片岡一則,ロナルドジェイムズクリスティ,西山伸宏,宮田完二郎,福島重人,松本有,野本貴大,加藤泰己
  • Industrial Property Rights Holder: 東京大学工学系研究科,東京大学工学系研究科,東京大学医学系研究科,東京大学医学系研究科,東京大学工学系研究科,東京大学医学系研究科,東京大学工学系研究科,ナノキャリア株式会社
  • Filing Date: 2012-01-16
  • Overseas
• [Patent(Industrial Property Rights)] 名称:粒子組成物および該粒子組成物を用いた医薬組成物 (2012)
  • Inventor(s): 片岡一則,ロナルドジェイムズクリスティ,西山伸宏,宮田完二郎,福島重人,松本有,野本貴大,加藤泰己
  • Industrial Property Rights Holder: 東京大学工学系研究科,東京大学工学系研究科,東京大学医学系研究科,東京大学医学系研究科,東京大学工学系研究科,東京大学医学系研究科,東京大学工学系研究科,ナノキャリア株式会社
  • Filing Date: 2012-01-16
  • Overseas
• [Patent(Industrial Property Rights)] 複合体微粒子およびその製造方法、ならびに該複合体微粒子を用いた薬学組成物 (2011)
  • Inventor(s): 片岡一則,宮田完二郎,西山伸宏,大 庭誠,山崎裕一,須磨知也,グダノハ,武元宏泰,松本有,野本貴大
  • Industrial Property Rights Holder: 国立大学法人東京大学
  • Industrial Property Number: 2011-552789
  • Filing Date: 2011-02-02
• [Patent(Industrial Property Rights)] 複合体微粒子およびその製造方法、ならびに該複合体微粒子を用いた薬学組成物 (2011)
  • Inventor(s): 片岡一則,宮田完二郎,西山伸宏,大 庭誠,山崎裕一,須磨知也,グダノハ,武元宏泰,松本有,野本貴大
  • Industrial Property Rights Holder: 国立大学法人東京大学
  • Filing Date: 2011-02-02
  • Overseas