| Project/Area Number |
23790049
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Physical pharmacy
|
|---|
| Research Institution | Kyushu University |
|---|
Principal Investigator |
|
|---|
| Research Collaborator |
YAMADA Ken-ichi 九州大学, 大学院薬学研究院, 准教授 (60346806)
ICHIKAWA Kazuhiro 九州大学, 先端融合医療レドックスナビ研究拠点, 教授 (10271115)
HYODO Fuminori 九州大学, 先端融合医療レドックスナビ研究拠点, 准教授 (10380693)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | イメージング / レドックス / 酸素濃度 / 炎症 / 生体イメージング / 酸化還元 / 活性酸素 / オーバーハウザーMRI |
|---|
| Research Abstract |
This study is aimed to develop the 3D mapping technique of Overhauser-enhanced MRI (OMRI), which provides non-invasively both redox status and oxygen with high-resolution, and MRI and to apply it to the mechanism analysis for gastrointestinal diseases. The algorithms for oxygen image and its superimposition with redox image were verified using a phantom. However, it was needed to improve the time-resolution of OMRI to obtain 3D information with adequate accuracy. It was founded that inflammatorysignal pathways and the downstream redox change expanded from the rectum toward the whole large intestine during the development of dextran sodium sulfate-induced colitis in mice. In near future, the improvement of accuracy precision of redox status and oxygen concentration would be expected if the performance upgrade of OMRI is achieved.
|
