| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
Cocrystallization is a pharmaceutical technology which provides an improvement on solid properties of active pharmaceutical ingredients without modification of its chemical structure. In this study, paracetamol (acetaminophen) was used as model drug substance and to clarify the formation mechanism of cocrystal in molecular level. As a result of exploring screening study in solid state using mechanochemical reaction, novel three cocrystals were discovered. In particular, the pharmaceutical cocrystal consisting of paracetamol and trimethylglycine (betaine) at molar ration of 1:1 indicated improved pharmaceutical properties such as compact moldability and dissolution behavior. In addition, preparing cocrystal in nanogram scale and evaluating by using microscopic Raman spectroscopy were achieved.
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