Study on the mechanism of anti-angiogenesis and tumorigenesis through genomic function of nuclear receptor

• Project/Area Number: 23790075
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Biological pharmacy
• Research Institution: University of Tsukuba
• Principal Investigator: NAKAJIMA Yuka 筑波大学, 生命環境系, 助教 (40399499)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 血管新生 / 腫瘍形成 / エストロゲン受容体 / 分子生物学 / エストロゲン受容体ベータ（ERb) / KLF5

Research Abstract

I found that ER ligands suppress tumor angiogenesis of androgen independent prostate cancer through novel non-genomic pathway of ERβ, and thereby inhibit tumor growth. Moreover, I also found that NFκB is novel target gene of ERβ non-genomic pathway, and identified some inhibitory compounds of NFκB activity. These findings may provide a suitable target for androgen independent prostate cancer treatment.

Research Products

• [Presentation] 新規核内授与体制御機構に基づいた腎性骨症治療薬の開発 (2012)
  • Author(s): 仲島由佳
  • Organizer: 第5回慢性腎臓病病態研究会
  • Place of Presentation: 東京
  • Year and Date: 2012-07-28
• [Presentation] ERβのノンクラシカル経路の前立腺癌進行における役割 (2012)
  • Author(s): 仲島由佳、刑部朝実、石川寛子、赤荻健介、柳澤純
  • Organizer: 転写代謝システム・転写研究会共催「若手ワークショップ@湯河原」
  • Place of Presentation: 湯河原
  • Year and Date: 2012-02-10
• [Presentation] エストロゲン受容体の新規ノンクラシカル経路を介した前立腺癌治療の可能性 (2012)
  • Author(s): 仲島由佳
  • Organizer: 第14回 UTPシンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2012-01-15
• [Presentation] KLF5-ERβ pathway is responsible for the contradictory effects of estrogen on prostate tumor formation (2011)
  • Author(s): Asami Osakabe, Yuka Nakajima, Hiroko Ishikawa, Junn Yanagisawa
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2011-12-14
• [Presentation] A novel ER antagonist suppresses prostate tumor growth by inhibiting ERβ-KLF5 pathway without estrogenic action (2011)
  • Author(s): Hiroko Ishikawa, Yuka Nakajima, Junn Yanagisawa
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2011-12-14
• [Presentation] KLF5-ERβ pathway is responsible for the biphasic effects of estrogen on prostate tumor growth (2011)
  • Author(s): Yuka Nakajima et al.
  • Organizer: 70^<th>Annual Meeting of Japanese Cancer Association
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-04
• [Presentation] Estrogen receptor ligands regulate prostate tumorformation through a nonclassical pathway that includes ERβ and KLF5 (2011)
  • Author(s): Yuka Nakajima et al
  • Organizer: The EMBO meeting 2011
  • Place of Presentation: オーストリア
  • Year and Date: 2011-09-11
• [Presentation] KLF5-ERβ pathway is responsible for the contradictory effects of estrogen on prostate tumor growth (2011)
  • Author(s): Asami Osakabe,Yuka Nakajima et al
  • Organizer: The EMBO meeting 2011
  • Place of Presentation: オーストリア
  • Year and Date: 2011-09-11
• [Presentation] KLF5-ERb; pathway is responsible for the contradictory effects of estrogen on prostate tumor formation (2011)
  • Author(s): Asami Osakabe, Hiroko Ishikawa, Yuka Nakajima, Junn Yanagisawa
  • Organizer: 第３４回 日本分子生物学会年会
  • Place of Presentation: 横浜、パシフィコ横浜
• [Presentation] KLF5-ERb pathway is responsible for the contradictory effects of estrogen on prostate tumor formation (2011)
  • Author(s): Hiroko Ishikawa, Asami Osakabe, Yuka Nakajima, Junn Yanagisawa
  • Organizer: 第３４回 日本分子生物学会年会
  • Place of Presentation: 横浜、パシフィコ横浜
• [Presentation] 新規核内受容体制御機構に基づいた腎性骨症治療薬の開発
  • Author(s): 仲島由佳
  • Organizer: 第５回慢性腎臓病病態研究会
  • Place of Presentation: 東京 経団連会館
  • Invited
• [Presentation] Estrogen receptor ligands regulate prostate tumor formation through a nonclassical pathway that includes ERb and KLF5
  • Author(s): Yuka Nakajima, Kensuke Akaogi, Asami Osakabe, Chie Yamaguchi, Hiroko Ishikawa, Junn Yanagisawa
  • Organizer: The EMBO meeting 2011
  • Place of Presentation: オーストリア
• [Presentation] KLF5-ERb; pathway is responsible for the biphasic effects of estrogen on prostate tumor growth
  • Author(s): Yuka Nakajima, Asami Osakabe, Chie Yamaguchi, Junn Yanagisawa
  • Organizer: 70th Annual Meeting of Japanese Cancer Association
  • Place of Presentation: 名古屋、名古屋国際会議場
• [Presentation] エストロゲン受容体の新規ノンクラシカル経路を介した前立腺癌治療の可能性
  • Author(s): 仲島由佳
  • Organizer: 第１４回 ＵＴＰシンポジウム(招待講演)
  • Place of Presentation: 東京、椿山荘
• [Book] がん基盤生物学-革新的シーズ育成に向けて- (2013)
  • Author(s): 仲島由佳、和久 剛、柳澤 純
  • Total Pages: 8
  • Publisher: (財)金原一郎記念医学医療振興財団/医学書院
• [Book] がん基盤生物学―革新的シーズ育成に向けて― (2013)
  • Author(s): 仲島由佳
  • Total Pages: 8
  • Publisher: 株式会社 南山堂
• [Book] 細胞核-構造と機能 (2011)
  • Author(s): 仲島由佳、山口智絵、石川寛子、柳澤 純
  • Total Pages: 2
  • Publisher: (財)金原一郎記念医学医療振興財団/医学書院
• [Book] 細胞核―構造と機能 (2011)
  • Author(s): 仲島由佳、山口智絵、石川寛子、柳澤純
  • Total Pages: 2
  • Publisher: （財）金原一郎記念医学医療振興財団/医学書院