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Transcriptional regulation of nuclear long noncoding RNA in mammalian cells

Research Project

Project/Area Number 23790077
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Biological pharmacy
Research InstitutionThe University of Tokyo

Principal Investigator

AKIMITSU Nobuyoshi  東京大学, アイソトープ総合センター, 准教授 (40294962)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywordsノンコーディング RNA / がん / 転写 / 53 / RNA / ノンコーディングRNA / 非コードRNA / がん抑制遺伝子
Research Abstract

In this study, I examined the function of MALAT1, a nuclear long noncoding RNA, in transcriptional regulation. I found that MALAT1 negatively regulates the promoter activity of p53, a well-known anti-cancer gene. This result can well-explain the relationship between MALAT1 and cancer based on gene regulation of p53.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (18 results)

All 2013 2012 Other

All Journal Article (16 results) (of which Peer Reviewed: 11 results) Presentation (1 results) Remarks (1 results)

  • [Journal Article] Psammaplin Ainhibits hepatitis C virus NS3 helicase, J.Natur. Med., in press.2013

    • Author(s)
      Salam KA., Furuta A., Noda N., Tsuneda S.Sekiguchi Y., Yamashita A., Moriishi K.,Nakakoshi M., Tsubuki M., Tani H.
    • Journal Title

      TanakaJ. and Akimitsu N.,

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Akimitsu N, Tanaka J, Tani H, Yamashita A, Moriishi K, Nakakoshi M, Tsubuki M, Sekiguchi Y, Tsuneda S, Noda N. (2013) Cholesterol sulfate as a potential inhibitor of hepatitis C virus NS3 helicase.2013

    • Author(s)
      Furuta A, Salam KA
    • Journal Title

      J. Enzyme Inhib. Med. Chem., inpress.

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] RNA ダイナミクスから迫 る生命現象2013

    • Author(s)
      秋光信佳
    • Journal Title

      薬事日報、3月特集号

    • Related Report
      2012 Final Research Report
  • [Journal Article] The RNA degradation pathway regulates the function of GAS5 a non-coding RNA in mammalian cells2013

    • Author(s)
      Tani T.Torimura M. and Akimitsu N.
    • Journal Title

      PLoS ONE.

      Volume: 8

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of hundreds of novel UPF1 target transcripts by direct determining whole transcriptomestability in mammalian cells2013

    • Author(s)
      Tani H., Imamachi N., Salam KA., Mizutani R., Ijiri K., Irie T., Yada T., Suzuki Y., and Akimitsu N., (
    • Journal Title

      RNA Biology

      Volume: 9 Pages: 1370-1379

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of both protease and helicase activities of hepatitis C virus NS3 by an ethyl acetate extract of marine sponge Amphimedon sp.2012

    • Author(s)
      Fujimoto Y., Salam KA., Furuta A., Matsuda Y., Fujita O., Tani H., Ikeda M., Kato N., Sakamoto N., Maekawa S., Enomoto N., de Voogd NJ., Nakakoshi M., Tsubuki M., Sekiguchi Y., Tsuneda S.Akimitsu N., Noda N., Yamashita A., Tanaka J. and Moriishi K., (
    • Journal Title

      PLoS ONE

      Volume: 7

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genome-wide determination of RNA stability reveals hundreds of short-lived non-coding transcripts in mammals2012

    • Author(s)
      Tani H., Mizutani R., Salam KA. Tano K., Ijiri K., Wakamatsu A., Isogai T., Suzuki Y. and Akimitsu N.,
    • Journal Title

      Genome Res.

      Volume: 22 Pages: 947-956

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of cis-and trans-acting factors involved in the localization of MALAT-1 noncoding RNA tonuclear speckles.2012

    • Author(s)
      Miyagawa R., Tano K., Mizuno R., Nakamura Y., Ijiri K., Rakwal R., Shibato J., Masuo Y., Mayeda A., Hirose T. and Akimitsu N.
    • Journal Title

      RNA.

      Volume: 18 Pages: 738-751

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification and characterization of novel genotoxic stress-inducible nuclear long noncoding RNAs in mammalian cells.2012

    • Author(s)
      Mizutani R., Wakamatsu A., Tanaka N., Yoshida H., Tochigi N., Suzuki Y., Oonishi T., Tani H., Tano K., Ijiri K., Isogai T. and Akimitsu N.
    • Journal Title

      PLoS ONE

      Volume: 7

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of hepatitis C virusreplication and viral helicase by ethyl acetate extract of the marine feather star Alloeocomatella polycladia.2012

    • Author(s)
      Yamashita A., Salam KA., Furuta A., Matsuda Y., Fujita O., Tani H., Fujita Y., Fujimoto Y., Ikeda M., Kato N., Sakamoto N., Maekawa S., Enomoto N., Nakakoshi M., Tsubuki M., Sekiguchi Y., Tsuneda S., Akimitsu N., Noda N., Tanaka J., Moriishi K.
    • Journal Title

      Marine Drugs

      Volume: 10 Pages: 744-761

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of hepatitis C virus NS3 helicase by Manoalide.2012

    • Author(s)
      Salam KA., Furuta A., Noda N., Tsuneda S., Sekiguchi Y., Yamashita A., Moriishi K., Nakakoshi M., Tsubuki M., Tani H., Tanaka J. and Akimitsu N.
    • Journal Title

      J. Nat. Prod.

      Volume: 75 Pages: 650-654

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] ゲノムワイドなRNA分解測定2012

    • Author(s)
      秋光信佳
    • Journal Title

      細胞工学別冊「次世代シークエンサー目的別アドバンストメソッド」

      Pages: 100-108

    • Related Report
      2012 Final Research Report
  • [Journal Article] ノンコーディング RNA から理解する「がん」のメカニズム2012

    • Author(s)
      秋光信佳
    • Journal Title

      科学フォーラム

      Volume: 338 Pages: 36-39

    • Related Report
      2012 Final Research Report
  • [Journal Article] 核内構造とエピジェネティック制御をつなぐ核内長鎖ノンコーディングRNA2012

    • Author(s)
      秋光信佳
    • Journal Title

      細胞工学

      Volume: 31 Pages: 917-922

    • Related Report
      2012 Final Research Report
  • [Journal Article] RNA の安定性を指標にして機能不明な長鎖ノンコーディング RNAの性質を定義する2012

    • Author(s)
      谷英典、水谷玲菜、鈴木穣、秋光信佳
    • Journal Title

      細胞工学

      Volume: 31 Pages: 926-927

    • Related Report
      2012 Final Research Report
  • [Journal Article] Identification of cis- and trans-acting factors involved in the localization of MALAT-1 noncoding RNA to nuclear speckles2012

    • Author(s)
      Miyagawa, R.
    • Journal Title

      RNA

      Volume: 18 Issue: 4 Pages: 738-751

    • DOI

      10.1261/rna.028639.111

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 核内RNA 分解機構を介した非コードRNA機能制御2013

    • Author(s)
      秋光信佳
    • Organizer
      日本薬学会113年会
    • Place of Presentation
      横浜市
    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://www.ric.u-tokyo.ac.jp/akimitsu/

    • Related Report
      2011 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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