Analysis of a novel prepro-BDNF expression and function
Project/Area Number |
23790080
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Biological pharmacy
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Research Institution | University of Toyama |
Principal Investigator |
FUKUCHI Mamoru 富山大学, 大学院・医学薬学研究部(薬学), 助教 (40432108)
|
Project Period (FY) |
2011 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | BDNF / スプライシング / 神経活動 / BDNF前駆体 |
Research Abstract |
In this study, I investigated the mechanism of mRNA expression of brain-derived neurotrophic factor (BDNF), which is involved in expressing a variety of neuronal functions. I found that RNA splicing of BDNF exon I-IX, which is one of alternative BDNF transcripts, was enhanced by Ca2+-CaMK signal evoked by neuronal activity. Moreover, a novel prepro-BDNF protein was generated from BDNF exon I-IX mRNA. These results provide a novel insight into BDNF expression in neurons
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Report
(3 results)
Research Products
(15 results)
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[Journal Article] Synthesis and biological evaluation of pyrethroid insecticide-derivatines as a chenical inducer for Bdnf mRNA expression in neurons2012
Author(s)
Matsuya, Y., Ihara, D., Fukuchi, M., Honma, D., Itoh, K., Tabuchi, A., Nemoto, H., Tsuda, M.
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Journal Title
Bioorg.Med.Chem.
Volume: 20
Issue: 8
Pages: 2564-2571
DOI
Related Report
Peer Reviewed
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[Journal Article] Deltamethrin, a type II pyrethroid insecticide, has neurotrophic effects on neurons with continuous activation of the Bdnf promoter2011
Author(s)
Ihara, D., Fukuchi, M., Honma, D., Takasaki, I., Ishikawa, M., Tabuchi, A.Tsuda, M.
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Journal Title
Neuropharmacol
Volume: 62
Issue: 2
Pages: 1091-1098
DOI
Related Report
Peer Reviewed
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