Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Research Abstract |
In this study, I investigated the mechanism of mRNA expression of brain-derived neurotrophic factor (BDNF), which is involved in expressing a variety of neuronal functions. I found that RNA splicing of BDNF exon I-IX, which is one of alternative BDNF transcripts, was enhanced by Ca2+-CaMK signal evoked by neuronal activity. Moreover, a novel prepro-BDNF protein was generated from BDNF exon I-IX mRNA. These results provide a novel insight into BDNF expression in neurons
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