Research for reward-basis decision making in drug abuse-dependent rat
| Project/Area Number |
23790082
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
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| Keywords | 意思決定 / 薬物依存症 / 覚せい剤 / ギャンブル試験 / 島皮質 / 線条体 / 薬物依存 |
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| Research Abstract |
In the present study, we developed a gambling test for rodents using a radial-arm maze to address the issue of decision-making in patients with drug dependence. Our findings suggest that chronic methamphetamine treatment may lead to alternations of reward-based decision-making. Aberrant activation of the cortico-striatal pathway from insular cortex to striatum may be associated with the impairment of reward-based decision-making in methamphetamine-dependent rats.
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Report
(3 results)
Research Products
(15 results)
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[Journal Article] Matrix metalloproteinase-9 contributes to kindled seizure development in pentylenetetrazole-treated mice by converting pro-BDNF to mature BDNF in the hippocampus2011
Author(s)
H Mizoguchi, J Nakade, M Tachibana, D Ibi, E Someya, H Koike, H Kamei, T Nabeshima, S Itohara, K Takuma, M Sawada, J Sato, K Yamada
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Journal Title
Journal of Neuroscience
Volume: 31
Issue: 36
Pages: 12963-12971
DOI
Related Report
Peer Reviewed
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