Research for reward-basis decision making in drug abuse-dependent rat

• Project/Area Number: 23790082
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Biological pharmacy
• Research Institution: Nagoya University
• Principal Investigator: MIZOGUCHI Hiroyuki 名古屋大学, 環境医学研究所, 助教 (70402568)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
• Keywords: 意思決定 / 薬物依存症 / 覚せい剤 / ギャンブル試験 / 島皮質 / 線条体 / 薬物依存

Research Abstract

In the present study, we developed a gambling test for rodents using a radial-arm maze to address the issue of decision-making in patients with drug dependence. Our findings suggest that chronic methamphetamine treatment may lead to alternations of reward-based decision-making. Aberrant activation of the cortico-striatal pathway from insular cortex to striatum may be associated with the impairment of reward-based decision-making in methamphetamine-dependent rats.

Research Products

• [Journal Article] Roles of matrix metalloproteinases and their targets in epileptogenesis and seizure (2013)
  • Author(s): Mizoguchi H
  • Journal Title: Clinical Psychopharmacology and Neuroscience Volume: in press
  • Peer Reviewed
• [Journal Article] Matrix metalloproteinase-9 contributes to kindled seizure development in pentylenetetrazole-treated mice by converting pro-BDNF to mature BDNF in the hippocampus (2011)
  • Author(s): H Mizoguchi, J Nakade, M Tachibana, D Ibi, E Someya, H Koike, H Kamei, T Nabeshima, S Itohara, K Takuma, M Sawada, J Sato, K Yamada
  • Journal Title: Journal of Neuroscience Volume: 31 Issue: 36 Pages: 12963-12971
  • DOI: 10.1523/jneurosci.3118-11.2011
  • Peer Reviewed
• [Journal Article] Matrix metalloproteinases contribute to neuronal dysfunction in animal models of drug dependence, Alzheimer’s disease, and epilepsy. (2011)
  • Author(s): Mizoguchi H, Yamada K and Nabeshima T
  • Journal Title: Biochem. Res. Int. Volume: 2011 Pages: 681385-681385
  • DOI: 10.1155/2011/681385
  • Peer Reviewed
• [Journal Article] oles of matrix metalloproteinases and their targets in epileptogenesis and seizure
  • Author(s): Mizoguchi H, Yamada K
  • Journal Title: Clin Psychopharmacol Neurosci Volume: (in press)
• [Presentation] 覚せい剤は報酬の利得・損失の評価異常を引き起こす (2012)
  • Author(s): 溝口博之、山田清文
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋
• [Presentation] Alteration of decision-making behavior is related to the overestimation of risk / benefit values in methamphetamine-treated rats (2012)
  • Author(s): Mizoguchi H, Yamada K
  • Organizer: 2012 ISBRA World congress
  • Place of Presentation: 札幌
• [Presentation] ニコチンの認知機能改善作用 (2012)
  • Author(s): 山田清文、溝口博之
  • Organizer: 平成 24 年度アルコール・薬物依存関連学会合同学術総会
  • Place of Presentation: 札幌
• [Presentation] 覚せい剤は報酬の利得・損失の評価異常を引き起こす. (2012)
  • Author(s): 溝口博之
  • Organizer: 第 35 回日本神経科学大会
  • Place of Presentation: 名古屋
• [Presentation] Alteration of decision-making behavior is related to the overestimation of risk / benefit values in methamphetamine-treated rats. (2012)
  • Author(s): Mizoguchi H
  • Organizer: 2012 ISBRA World congress
  • Place of Presentation: 札幌
• [Presentation] 報酬に基づく意思決定機構に対する覚せい剤の効果 (2011)
  • Author(s): 溝口博之、山田清文
  • Organizer: 平成 23 年度アルコール・薬物依存関連学会合同学術総会
  • Place of Presentation: 名古屋
• [Presentation] 報酬に基づく意思決定機構に対する覚せい剤の効果 (2011)
  • Author(s): 溝口博之、山田清文
  • Organizer: 第21回日本臨床精神薬理学会、第41回日本神経精神薬理学会合同年会
  • Place of Presentation: 東京
• [Presentation] 報酬に基づく意思決定に対するmethamphetamineの影響 (2011)
  • Author(s): 溝口博之、山田清文
  • Organizer: 第120回日本薬理学会近畿部会
  • Place of Presentation: 京都
• [Presentation] 報酬に基づく意思決定機構に対する覚せい剤の効果
  • Author(s): 溝口博之、佐藤 純、山田清文
  • Organizer: 平成23年度アルコール・薬物依存関連学会合同学術総会
  • Place of Presentation: 名古屋
• [Presentation] 報酬に基づく意思決定機構に対する覚せい剤の効果：放射状迷路を用いた小動物用ギャンブルテスト
  • Author(s): 溝口博之、福本和哉、Erika Toth、佐藤 純、山田清文
  • Organizer: 第２１回日本臨床精神神経薬理学会、第４１回日本神経精神薬理学会合同年会
  • Place of Presentation: 東京
• [Remarks]
  • URL: http://www.riem.nagoya-u.ac.jp/center.html