The exploration of antidepressant effects in the hypothalamic nuclei

• Project/Area Number: 23790084
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Biological pharmacy
• Research Institution: Kyoto University
• Principal Investigator: SEGI Eri 京都大学, 大学院・薬学研究科, 特定准教授 (70378628)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 神経生物学 / 抗うつ治療 / 遺伝子発現 / 視床下部 / 摂食 / 電気けいれん療法 / 高脂肪食

Research Abstract

The purpose of the study is to explore antidepressant effects of electroconvulsive seizures (ECS) in the hypothalamic nuclei.
(1) ECS down-regulates gene expression of cholecystokinin, which is suggested as a modulator of the stress responses, in the paraventricular hypothalamus.
(2) ECS up-regulates gene expression of anorexigenic factors in the ventromedial hypothalamus, and decreases food intake via ventromedial hypothalamus function. This study suggests a role in the regulation energy homeostasis by ECS.

Research Products

• [Journal Article] Electroconvulsive seizures activate anorexigenic signals in the ventromedial nuclei of the hypothalamus. (2013)
  • Author(s): Segi-Nishida, E., Sukeno, M., Imoto, Y., Kira, T., Sakaida, M., Tsuchiya, S., Sugimoto, Y., and Okuno, Y.
  • Journal Title: Neuropharmacol. Volume: 71 Pages: 164-173
  • DOI: 10.1016/j.neuropharm.2013.03.033
  • NAID: 120005295921
  • Peer Reviewed
• [Journal Article] DNAマイクロアレイ解析による脂質メディエーターの機能研究 (2013)
  • Author(s): 瀬木（西田）恵里
  • Journal Title: 遺伝子医学MOOK Volume: 24
• [Journal Article] Prostaglandin E_2-mediated attenuation of mesocortical dopaminergic pathway is critical for susceptibility to repeated social defeat stress in mice (2012)
  • Author(s): Tanaka, K.,* Furuyashiki, T.*#, Kitaoka, S.*, Senzai, Y.*, Imoto, Y., Segi-Nishida, E., Deguchi, Y., Breyer, R.M., Breyer, M.D., Narumiya, S.#(*equally contribut ed; #co-corresponding authors)
  • Journal Title: J.Neurosci. Volume: 32 Issue: 12 Pages: 4319-4329
  • DOI: 10.1523/jneurosci.5952-11.2012
  • Peer Reviewed
• [Journal Article] Exploration of New Molecular Mechanisms for Antidepressant Actions of Electroconvulsive Seizure (2011)
  • Author(s): Segi-Nishida E
  • Journal Title: Biological and Pharmaceutical Bulletin Volume: 34 Issue: 7 Pages: 939-944
  • DOI: 10.1248/bpb.34.939
  • NAID: 130000738078
  • ISSN: 0918-6158, 1347-5215
  • Peer Reviewed
• [Journal Article] Prostaglandin E_2-EP4signaling suppresses adipocyte differentiation in mouse embryonic fibroblasts via an autocrine mechanism (2011)
  • Author(s): Inazumi, T., Shirata, N., Morimoto, K., Takano, H., Nishida, S.E., Sugimoto, Y.
  • Journal Title: J Lipid Res Volume: 52 Issue: 8 Pages: 1500-1508
  • DOI: 10.1194/jlr.m013615
  • Peer Reviewed
• [Journal Article] うつ病の病態メカニズムの探求 (2011)
  • Author(s): 瀬木(西田)恵里
  • Journal Title: ファルマシア Volume: 47巻 Pages: 813-818
  • URL: http://farumashia.pharm.or.jp/mokuji/2011/47-09.html
  • Peer Reviewed
• [Journal Article] うつ病の病態メカニズムの探求 (2011)
  • Author(s): 瀬木( 西田 ) 恵里
  • Journal Title: ファルマシア Volume: 47 Pages: 813-818
  • Peer Reviewed
• [Presentation] Electroconvulsive seizures suppress food intake via activation of ventromedial nuclei of hypothalamus (2012)
  • Author(s): 瀬木(西田) 恵里、吉良俊彦、助野真美子
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2012-09-21
• [Presentation] Electroconvulsive seizures suppress food intake via activation of ventromedial nuclei of hypothalamus (2012)
  • Author(s): 瀬木(西田)恵里
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋国際会議場（愛知県）
• [Presentation] The effect of electroconvulsive seizure on transcriptional changes in the mouse paraventricular nucleus of hypothalamus. (2011)
  • Author(s): Segi-Nishida E, Kira T, Sukeno M
  • Organizer: 北米神経科学学会
  • Place of Presentation: ワシントン国際会議場・アメリカ
  • Year and Date: 2011-11-13
• [Presentation] The effect of electroconvulsive seizure on transcriptional changes in the mouse paraventricular nucleus of hypothalamus (2011)
  • Author(s): Segi-Nishida E
  • Organizer: 北米神経科学学会
  • Place of Presentation: ワシントン、アメリカ合衆国
• [Book] DNA マイクロアレイ解析による脂質メディエーターの機能研究(第1 章12 節)、遺伝子医学 MOOK24 号、最新生理活性脂質研究 (2013)
  • Author(s): 瀬木(西田)恵里
  • Publisher: (編者)青木淳賢、杉本幸彦、村上 誠
• [Remarks]
  • URL: http://pharminfo.pharm.kyoto-u.ac.jp/segi.html
• [Remarks] 京都大学薬学研究科システム創薬科学講座 メンバー 瀬木（西田）恵里
  • URL: http://pharminfo.pharm.kyoto-u.ac.jp/segi.html
• [Remarks]
  • URL: http://pharminfo.pharm.kyoto-u.ac.jp/content.html
• [Patent(Industrial Property Rights)] ピペラジン誘導体およびその用途 (2012)
  • Inventor(s): 京都大学:高須清誠、奥野恭史、瀬木恵里他 6 名
  • Industrial Property Rights Holder: 京都大学:高須清誠、奥野恭史、瀬木恵里他 6 名
  • Industrial Property Number: 2012-177572
  • Filing Date: 2012-05-15
• [Patent(Industrial Property Rights)] ピペラジン誘導体およびその用途 (2012)
  • Inventor(s): 高須清誠、奥野恭史、瀬木恵里他6名
  • Industrial Property Rights Holder: 高須清誠、奥野恭史、瀬木恵里他6名
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2012-177572
  • Filing Date: 2012-05-10