Strategy for the prevention of obesity by the regulation of Lipin1
| Project/Area Number |
23790087
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | Osaka University |
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Principal Investigator |
ISHIMOTO Kenji 大阪大学, 医学部附属病院, 特任助教(常勤) (00572984)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | Lipin1 / 脂質代謝調節因子 / トリグリセリド生合成 / 脂肪酸酸化 / 肥満 / 細部内局在 / プロテオミクス / ユビキチン-プロテアソーム / ユビキチン―プロテアソーム / タンパク質分解制御 / 細胞内局在 / 免疫沈降法 |
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| Research Abstract |
We set out to search for novel mechanisms for regulation of Lipin1 protein by using proteomics analysis. As a result, we have identified the glycolysis protein, the ubiquitin-proteasome protein, and the proline biosynthetic protein as novel Lipin1 interacting factors. We next examined interaction between Lipin1 and the ubiquitin-proteasome protein actually, and to reveal the proteolytic mechanism for Lipin1. Our findings suggest that Lipin1 is polyubiqutinated by the ubiquitin-proteasome protein, and degraded by ubiquitin-proteasome system.
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Report
(3 results)
Research Products
(23 results)
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[Journal Article] Transcriptional activation of low-density lipoprotein receptor gene by DJ-1 and effect of DJ-1 on cholesterol homeostasis2012
Author(s)
Yamaguchi, S., Yamane, T., Takahashi-Niki, K., Kato, I., Niki, T., Goldberg, M. S., Shen, J., Ishimoto, K., Doi, T., Iguchi-Ariga, S. M. M., Ariga, H.
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Journal Title
PLoS ONE
Volume: 7
Issue: 5
Pages: e38144-e38144
DOI
Related Report
Peer Reviewed
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[Journal Article] Fenofibrate suppresses growth of the human hepatocellular carcinoma cell via PPARα-independent mechanisms.2011
Author(s)
Yamasaki D, Kawabe N, Nakamura H, Tachibana K, Ishimoto K, Tanaka T, Aburatani H, Sakai J, Hamakubo T, Kodama T, Doi T.
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Journal Title
Eur. J. Cell Biol.
Volume: 90(8)
Pages: 657-664
Related Report
Peer Reviewed
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[Journal Article] Human mannose-binding lectin 2 is directly regulated by peroxisome proliferator-activated receptors (PPARs) via a peroxisome proliferator responsive element.
Author(s)
Tachibana K, Takeuchi K, Inada H, Sugimoto K, Ishimoto K, Yamashita M, Maegawa T, Yamasaki D, Osada S, Tanaka T, Rakugi H, Hamakubo T, Sakai J, Kodama T, Doi T.
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Journal Title
J. Biochem.
Volume: (in press)
Related Report
Peer Reviewed
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[Presentation] ヒト核内受容体 PPARαによる生体防御レクチン MBL2 の発現制御機構の解析2012
Author(s)
橘敬祐,竹内健太郎,稲田大彦,杉本研,石本憲司,田中十志也,楽木宏実,浜窪隆雄,酒井寿郎,児玉龍彦,沢村達也,土井健史
Organizer
第121回 日本薬理学会近畿支部会
Place of Presentation
徳島
Related Report
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[Presentation] 転写制御因子を介したミトコンドリアの脂肪酸酸化制御の解析2011
Author(s)
山下雅礼,橘敬祐,杉本研,秋山恵麻,石本憲司,山崎大典,岩成宏子,田中十志也,望月康弘,楽木宏実,酒井寿郎,浜窪隆雄,児玉龍彦,土井健史
Organizer
第34回 日本分子生物学会年会
Place of Presentation
横浜
Related Report
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[Presentation] ヒストンメチル化酵素 SETDB1 の細胞内局在の解析2011
Author(s)
後藤英子,橘敬祐,内原佳恵,川又那津子,石本憲司,岩成宏子,川村猛,望月康弘,酒井寿郎,浜窪隆雄,児玉龍彦,土井健史
Organizer
第84回 日本生化学会年会
Place of Presentation
京都
Related Report
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[Presentation] ヒストンメチル化酵素 SETDB1 はメチル基供与体 SAM の輸送体になり得るか?2011
Author(s)
橘敬祐,後藤英子,内原佳恵,川又那津子,石本憲司,山崎大典,岩成宏子,望月康弘,酒井寿郎,浜窪隆雄,児玉龍彦,土井健史
Organizer
第6回 トランスポーター研究会年会
Place of Presentation
仙台
Related Report
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