| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
We observed that basic fibroblast growth factor dysregulates glucose metabolism of adipocyte via expression of hypoxia-inducible factor-1alpha, indicating that expression of hypoxia-inducible factor-1alpha involves in development of diabetes mellitus. Therefore, we prepared an adipocyte-specific hypoxia inducible factor-1alpha knockout mice and observed the phenotype. The mice exhibited improved insulin sensitivity and glucose tolerance under obese conditions compared with wild type mice. These results suggested that hypoxia-inducible factor-1alpha plays an important role in development of obesity-induced diabetes.
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